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Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)

Ekaterina Yuryevna Levashova 1
Ekaterina Yuryevna Levashova
, 
Andrey Anatol'evich Firsov 1
Andrey Anatol'evich Firsov
, 
Olga Yurievna Bakulina 1
Olga Yurievna Bakulina
, 
Anatoly Andreevich Peshkov 1
Anatoly Andreevich Peshkov
, 
Evgeny Victorovich Kanov 1
Evgeny Victorovich Kanov
, 
Raul Radikovich Gainetdinov 1
Raul Radikovich Gainetdinov
, 
Mikhail Yur'evich Krasavin 1, 2
Mikhail Yur'evich Krasavin
10.1016/j.mencom.2021.07.016
Published 2021-07-07
Communication , Volume 31, Issue 4, 488-489
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Levashova E. Y. et al. Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1) // Mendeleev Communications. 2021. Vol. 31. No. 4. pp. 488-489.
GOST all authors (up to 50) Copy
Levashova E. Y., Firsov A. A., Bakulina O. Y., Peshkov A. A., Kanov E. V., Gainetdinov R. R., Krasavin M. Y. Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1) // Mendeleev Communications. 2021. Vol. 31. No. 4. pp. 488-489.
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TY - JOUR
DO - 10.1016/j.mencom.2021.07.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.016
TI - Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)
T2 - Mendeleev Communications
AU - Levashova, Ekaterina Yuryevna
AU - Firsov, Andrey Anatol'evich
AU - Bakulina, Olga Yurievna
AU - Peshkov, Anatoly Andreevich
AU - Kanov, Evgeny Victorovich
AU - Gainetdinov, Raul Radikovich
AU - Krasavin, Mikhail Yur'evich
PY - 2021
DA - 2021/07/07
PB - Mendeleev Communications
SP - 488-489
IS - 4
VL - 31
ER -
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@article{2021_Levashova,
author = {Ekaterina Yuryevna Levashova and Andrey Anatol'evich Firsov and Olga Yurievna Bakulina and Anatoly Andreevich Peshkov and Evgeny Victorovich Kanov and Raul Radikovich Gainetdinov and Mikhail Yur'evich Krasavin},
title = {Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.016},
number = {4},
pages = {488--489},
doi = {10.1016/j.mencom.2021.07.016}
}
MLA
Cite this
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Levashova, Ekaterina Yuryevna, et al. “Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1).” Mendeleev Communications, vol. 31, no. 4, Jul. 2021, pp. 488-489. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.016.

Abstract

Rare cis-configured 2,4-disubstituted 1-alkylpyridines were envisioned as ligands for trace amine associated receptor 1 (TAAR1). They were synthesized in diastereomerically pure form with the decarboxylative Castagnoli–Cushman reac-tion followed by two reduction events. Despite showing no affinity to TAAR1 as was anticipated, these novel, druglike and CNS-focused compounds will be of much utility in sub-sequent lead generation pursuits.

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