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Antimicrobial screening of a historical collection of over 140 000 small molecules

Victor Vladimirovich Semenov 1
Victor Vladimirovich Semenov
, 
Mikhail Mikhailovich Raihstat 1
Mikhail Mikhailovich Raihstat
, 
Leonid Dmitrievich Konyushkin 1
Leonid Dmitrievich Konyushkin
, 
Roman V Semenov 1
Roman V Semenov
, 
Mark A.T. Blaskovich 2
Mark A.T. Blaskovich
, 
Johannes Zuegg 2
Johannes Zuegg
, 
Alysha G Elliott 2
Alysha G Elliott
, 
Karl A Hansford 2
Karl A Hansford
, 
Matthew A Cooper 2
Matthew A Cooper
10.1016/j.mencom.2021.07.015
Published 2021-07-07
Communication , Volume 31, Issue 4, 484-487
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Semenov V. V. et al. Antimicrobial screening of a historical collection of over 140 000 small molecules // Mendeleev Communications. 2021. Vol. 31. No. 4. pp. 484-487.
GOST all authors (up to 50) Copy
Semenov V. V., Raihstat M. M., Konyushkin L. D., Semenov R. V., Blaskovich M. A., Zuegg J., Elliott A. G., Hansford K. A., Cooper M. A. Antimicrobial screening of a historical collection of over 140 000 small molecules // Mendeleev Communications. 2021. Vol. 31. No. 4. pp. 484-487.
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TY - JOUR
DO - 10.1016/j.mencom.2021.07.015
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.015
TI - Antimicrobial screening of a historical collection of over 140 000 small molecules
T2 - Mendeleev Communications
AU - Semenov, Victor Vladimirovich
AU - Raihstat, Mikhail Mikhailovich
AU - Konyushkin, Leonid Dmitrievich
AU - Semenov, Roman V
AU - Blaskovich, Mark A.T.
AU - Zuegg, Johannes
AU - Elliott, Alysha G
AU - Hansford, Karl A
AU - Cooper, Matthew A
PY - 2021
DA - 2021/07/07
PB - Mendeleev Communications
SP - 484-487
IS - 4
VL - 31
ER -
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@article{2021_Semenov,
author = {Victor Vladimirovich Semenov and Mikhail Mikhailovich Raihstat and Leonid Dmitrievich Konyushkin and Roman V Semenov and Mark A.T. Blaskovich and Johannes Zuegg and Alysha G Elliott and Karl A Hansford and Matthew A Cooper},
title = {Antimicrobial screening of a historical collection of over 140 000 small molecules},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.015},
number = {4},
pages = {484--487},
doi = {10.1016/j.mencom.2021.07.015}
}
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MLA Copy
Semenov, Victor Vladimirovich, et al. “Antimicrobial screening of a historical collection of over 140 000 small molecules.” Mendeleev Communications, vol. 31, no. 4, Jul. 2021, pp. 484-487. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.015.

Abstract

Most of the chemical compound collection (currently about 200 000), assembled at the N. D. Zelinsky Institute of Organic Chemistry over the past 30 years, has been screened for antimicrobial activity against five ESKAPE pathogens and two fungi at the University of Queensland on a charitable basis. A total of 2517 active molecules (MIC ≤ 32 μg ml–1) were found, of which about 10% are active at very low concentrations (MIC ≤ 1 μg ml–1). Structures of 142 012 compounds and experimental data on their antimicrobial activity are publicly available through the demo version of the CheD software and the public database of the Community for Open Antimicrobial Drug Discovery.

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