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New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors

Sherif M.H. Sanad 1
Sherif M.H. Sanad
, 
Ahmed E.M. Mekky 1
Ahmed E.M. Mekky
, 
Ahmed Y Said 1
Ahmed Y Said
, 
Mohamed A.A. Elneairy 1
Mohamed A.A. Elneairy
10.1016/j.mencom.2021.04.029
Published 2021-04-28
Communication , Volume 31, Issue 3, 370-372
22
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Sanad S. M. et al. New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors // Mendeleev Communications. 2021. Vol. 31. No. 3. pp. 370-372.
GOST all authors (up to 50) Copy
Sanad S. M., Mekky A. E., Said A. Y., Elneairy M. A. New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors // Mendeleev Communications. 2021. Vol. 31. No. 3. pp. 370-372.
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TY - JOUR
DO - 10.1016/j.mencom.2021.04.029
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.029
TI - New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors
T2 - Mendeleev Communications
AU - Sanad, Sherif M.H.
AU - Mekky, Ahmed E.M.
AU - Said, Ahmed Y
AU - Elneairy, Mohamed A.A.
PY - 2021
DA - 2021/04/28
PB - Mendeleev Communications
SP - 370-372
IS - 3
VL - 31
ER -
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@article{2021_Sanad,
author = {Sherif M.H. Sanad and Ahmed E.M. Mekky and Ahmed Y Said and Mohamed A.A. Elneairy},
title = {New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.029},
number = {3},
pages = {370--372},
doi = {10.1016/j.mencom.2021.04.029}
}
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Sanad, Sherif M.H., et al. “New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors.” Mendeleev Communications, vol. 31, no. 3, Apr. 2021, pp. 370-372. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.029.

Keywords

[1,2,4]triazolo[4,3-a]pyrimidinones
Antibacterial activity
heterocyclization
hybrid molecules
MRSA inhibitors
pyrimidinones
Smiles-type reaction
thieno[2,3-b]pyridines
VRE inhibitors

Abstract

New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinones were obtained by the [5+1] heterocyclization of the appropriate thieno[2,3-b]pyridines followed by the Smiles-type reaction protocol. In general, the triazoles tested exhibited better antibacterial activity against Gram-positive than against Gram-negative bacterial strains. Compoundscontaining 3-acetyl-1-(4-methoxyphenyl)[1,2,4]triazole unit demonstrated more potent inhibitory activities than the reference Linezolid.

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