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Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives

Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
, 
Nikita Andreevich Frolov 1
Nikita Andreevich Frolov
, 
Alexandra Pavlovna Minaeva 1, 2
Alexandra Pavlovna Minaeva
, 
Elena Vladimirovna Detusheva 3
Elena Vladimirovna Detusheva
, 
Yana V Derkach 1, 2
Yana V Derkach
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.1016/j.mencom.2021.04.028
Published 2021-04-28
Communication , Volume 31, Issue 3, 368-369
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Vereshchagin A. N. et al. Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives // Mendeleev Communications. 2021. Vol. 31. No. 3. pp. 368-369.
GOST all authors (up to 50) Copy
Vereshchagin A. N., Frolov N. A., Minaeva A. P., Detusheva E. V., Derkach Y. V., Egorov M. P. Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives // Mendeleev Communications. 2021. Vol. 31. No. 3. pp. 368-369.
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TY - JOUR
DO - 10.1016/j.mencom.2021.04.028
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.028
TI - Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives
T2 - Mendeleev Communications
AU - Vereshchagin, Anatoly Nikolaevich
AU - Frolov, Nikita Andreevich
AU - Minaeva, Alexandra Pavlovna
AU - Detusheva, Elena Vladimirovna
AU - Derkach, Yana V
AU - Egorov, Mikhail Petrovich
PY - 2021
DA - 2021/04/28
PB - Mendeleev Communications
SP - 368-369
IS - 3
VL - 31
ER -
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@article{2021_Vereshchagin,
author = {Anatoly Nikolaevich Vereshchagin and Nikita Andreevich Frolov and Alexandra Pavlovna Minaeva and Elena Vladimirovna Detusheva and Yana V Derkach and Mikhail Petrovich Egorov},
title = {Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.028},
number = {3},
pages = {368--369},
doi = {10.1016/j.mencom.2021.04.028}
}
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Vereshchagin, Anatoly Nikolaevich, et al. “Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives.” Mendeleev Communications, vol. 31, no. 3, Apr. 2021, pp. 368-369. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.028.

Keywords

antibacterial agents
biological activity
pyridinium salts
tris-quaternary ammonium compounds

Abstract

Novel tris(4-alkylaminopyridin-1-ium) trichlorides with alkylcyanuric spacer were synthesized by quaternization of 4-alkylaminopyridines with tris(2-chloroethyl) cyanurate. The obtained compounds were evaluated for microbiological activity against five pathogenic bacterial strains (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Acinobacter baumannii, Pseudomonas aeruginosa). The results indicate the presence of pronounced antibacterial properties in this group of compounds.

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