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N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells

Anna V Evdokimova 1
Anna V Evdokimova
, 
Alexander Aleksandrovich Alexeev 1
Alexander Aleksandrovich Alexeev
, 
Evgeniya Vladimirovna Nurieva 1
Evgeniya Vladimirovna Nurieva
, 
Elena Rudol'fovna Milaeva 1, 2
Elena Rudol'fovna Milaeva
, 
Sergei A Kuznetsov 3
Sergei A Kuznetsov
, 
Ol'ga Nikolaevna Zefirova 1, 2
Ol'ga Nikolaevna Zefirova
10.1016/j.mencom.2021.04.003
Published 2021-04-28
Communication , Volume 31, Issue 3, 288-290
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Evdokimova A. V. et al. N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells // Mendeleev Communications. 2021. Vol. 31. No. 3. pp. 288-290.
GOST all authors (up to 50) Copy
Evdokimova A. V., Alexeev A. A., Nurieva E. V., Milaeva E. R., Kuznetsov S. A., Zefirova O. N. N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells // Mendeleev Communications. 2021. Vol. 31. No. 3. pp. 288-290.
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TY - JOUR
DO - 10.1016/j.mencom.2021.04.003
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.003
TI - N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells
T2 - Mendeleev Communications
AU - Evdokimova, Anna V
AU - Alexeev, Alexander Aleksandrovich
AU - Nurieva, Evgeniya Vladimirovna
AU - Milaeva, Elena Rudol'fovna
AU - Kuznetsov, Sergei A
AU - Zefirova, Ol'ga Nikolaevna
PY - 2021
DA - 2021/04/28
PB - Mendeleev Communications
SP - 288-290
IS - 3
VL - 31
ER -
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@article{2021_Evdokimova,
author = {Anna V Evdokimova and Alexander Aleksandrovich Alexeev and Evgeniya Vladimirovna Nurieva and Elena Rudol'fovna Milaeva and Sergei A Kuznetsov and Ol'ga Nikolaevna Zefirova},
title = {N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.003},
number = {3},
pages = {288--290},
doi = {10.1016/j.mencom.2021.04.003}
}
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Cite this
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Evdokimova, Anna V., et al. “N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells.” Mendeleev Communications, vol. 31, no. 3, Apr. 2021, pp. 288-290. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.04.003.

Keywords

cancer cell morphology
cycloalka[d]thiazoles
heterocyclization
isothioureas
lung carcinoma A549
thiazolin-2-amines
thioureas
verubulin

Abstract

Bicyclic isothioureas of N-(4-methoxyphenyl)-2-aminocycloalkane[d]thiazole type were obtained using intramolecular electrophilic cyclization of N-(cycloalk-2-enyl)-N′-(4-methoxyphenyl)thioureas. Isothiourea fused with sevenmembered ring caused noticeable changes of the morphology of human lung carcinoma cells A549, but without affecting their microtubule net.

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