Keywords
N,O-acetals
aminals
arylamines
chroman-2-amines
nucleophilic substitution
transacetalization
transamination
Abstract
Reaction between 2-piperidinochromane and (hetero)aromatic amines in the presence of pyridinium tosylate affords the products of replacement of the piperidine fragment by the (hetero)arylamino moiety in good yields. This single-stage process opens facile and efficient way to the functionalized N-arylchroman-2-amines.
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