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Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives

Pham T Tham 1
Pham T Tham
, 
Pham T Chinh 2
Pham T Chinh
, 
Nguyen V Tuyen 3
Nguyen V Tuyen
, 
Duong N Bang 2
Duong N Bang
, 
Dinh T Van 2, 4
Dinh T Van
, 
Vu T Kien 2
Vu T Kien
, 
Hoang T Thanh 2
Hoang T Thanh
, 
Duong H Quynh 2, 3
Duong H Quynh
, 
Vu D Cuong 2, 5
Vu D Cuong
, 
Nguyen H Thanh 2, 3
Nguyen H Thanh
, 
Alfonso Perez Encabo 6
Alfonso Perez Encabo
10.1016/j.mencom.2021.03.022
Published 2021-03-03
Communication , Volume 31, Issue 2, 213-215
5
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Tham P. T. et al. Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 213-215.
GOST all authors (up to 50) Copy
Tham P. T., Chinh P. T., Tuyen N. V., Bang D. N., Van D. T., Kien V. T., Thanh H. T., Quynh D. H., Cuong V. D., Thanh N. H., Encabo A. P. Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 213-215.
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TY - JOUR
DO - 10.1016/j.mencom.2021.03.022
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.022
TI - Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives
T2 - Mendeleev Communications
AU - Tham, Pham T
AU - Chinh, Pham T
AU - Tuyen, Nguyen V
AU - Bang, Duong N
AU - Van, Dinh T
AU - Kien, Vu T
AU - Thanh, Hoang T
AU - Quynh, Duong H
AU - Cuong, Vu D
AU - Thanh, Nguyen H
AU - Encabo, Alfonso Perez
PY - 2021
DA - 2021/03/03
PB - Mendeleev Communications
SP - 213-215
IS - 2
VL - 31
ER -
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@article{2021_Tham,
author = {Pham T Tham and Pham T Chinh and Nguyen V Tuyen and Duong N Bang and Dinh T Van and Vu T Kien and Hoang T Thanh and Duong H Quynh and Vu D Cuong and Nguyen H Thanh and Alfonso Perez Encabo},
title = {Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.022},
number = {2},
pages = {213--215},
doi = {10.1016/j.mencom.2021.03.022}
}
MLA
Cite this
MLA Copy
Tham, Pham T., et al. “Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives.” Mendeleev Communications, vol. 31, no. 2, Mar. 2021, pp. 213-215. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.022.

Keywords

anticancer
cytotoxicity
piperazine-2,5-diones
plinabulin
quinoline

Abstract

A series of new plinabulin-quinoline derivatives and their simplified analogues was obtained from N,N′-diacetyl-2,5- diketopiperazines utilizing its aldol condensation with benzaldehydes. One compound showed strong activity related to three (KB, HepG2 and Lu) cancer cell lines while two other compounds demonstrated high potencies against breast carcinoma cell line (MCF-7).

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