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First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical

Natalia Evgen'evna Borisova 1
Natalia Evgen'evna Borisova
, 
Marina Alekseevna Orlova 1, 2
Marina Alekseevna Orlova
, 
Valery A Knizhnikov 3
Valery A Knizhnikov
, 
Varvara Konstantinovna Dolgova 1
Varvara Konstantinovna Dolgova
, 
Marina Dmitrievna Reshetova 1
Marina Dmitrievna Reshetova
, 
Alexey Pavlovich Orlov 1
Alexey Pavlovich Orlov
10.1016/j.mencom.2021.03.020
Published 2021-03-03
Communication , Volume 31, Issue 2, 207-209
9
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Borisova N. E. et al. First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 207-209.
GOST all authors (up to 50) Copy
Borisova N. E., Orlova M. A., Knizhnikov V. A., Dolgova V. K., Reshetova M. D., Orlov A. P. First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 207-209.
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TY - JOUR
DO - 10.1016/j.mencom.2021.03.020
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.020
TI - First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical
T2 - Mendeleev Communications
AU - Borisova, Natalia Evgen'evna
AU - Orlova, Marina Alekseevna
AU - Knizhnikov, Valery A
AU - Dolgova, Varvara Konstantinovna
AU - Reshetova, Marina Dmitrievna
AU - Orlov, Alexey Pavlovich
PY - 2021
DA - 2021/03/03
PB - Mendeleev Communications
SP - 207-209
IS - 2
VL - 31
ER -
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@article{2021_Borisova,
author = {Natalia Evgen'evna Borisova and Marina Alekseevna Orlova and Valery A Knizhnikov and Varvara Konstantinovna Dolgova and Marina Dmitrievna Reshetova and Alexey Pavlovich Orlov},
title = {First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.020},
number = {2},
pages = {207--209},
doi = {10.1016/j.mencom.2021.03.020}
}
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MLA Copy
Borisova, Natalia Evgen'evna, et al. “First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical.” Mendeleev Communications, vol. 31, no. 2, Mar. 2021, pp. 207-209. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.020.

Keywords

clearance
conjugates
mouse model
pyridine-2,6-dicarboxamide
radioactivity
ruthenium-97

Abstract

A new peptidomimetic conjugate of natural methionine and pyridine-2,6-dicarboxylate was synthesized and evaluated as a potential ligand for 97Ru radiopharmaceuticals. The distribution of this radiopharmaceutical in mice was investigated. A fundamental difference was found in the distribution and excretion of ruthenium complex and free ruthenium ion in the body, which suggests a difference in their transport pathways due to the stability of the complex in the body.

References

1.
Ruthenium-based chemotherapeutics: are they ready for prime time?
Antonarakis E.S., Emadi A.
Cancer Chemotherapy and Pharmacology, 2010
3.
Biological activity of ruthenium nitrosyl complexes
Tfouni E., Truzzi D.R., Tavares A., Gomes A.J., Figueiredo L.E., Franco D.W.
Nitric Oxide - Biology and Chemistry, 2012
4.
A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core
Wu B., Ong M.S., Groessl M., Adhireksan Z., Hartinger C.G., Dyson P.J., Davey C.A.
Chemistry - A European Journal, 2011
5.
The binding properties of two antitumor ruthenium(III) complexes to apotransferrin.
Kratz F., Hartmann M., Keppler B., Messori L.
Journal of Biological Chemistry, 1994
6.
The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways
Chatterjee S., Kundu S., Bhattacharyya A., Hartinger C.G., Dyson P.J.
Journal of Biological Inorganic Chemistry, 2008
8.
69mZn-containing radiopharmaceuticals: a novel approach to molecular design
Orlova M.A., Trofimova T.P., Aliev R.A., Orlov A.P., Nikulin S.V., Proshin A.N., Kalmykov S.N.
Journal of Radioanalytical and Nuclear Chemistry, 2016
9.
Separation and recovery of ruthenium: a review
Swain P., Mallika C., Srinivasan R., Mudali U.K., Natarajan R.
Journal of Radioanalytical and Nuclear Chemistry, 2013
10.
10.1016/j.mencom.2021.03.020_sbref0030b
Suh
J. Korean Chem. Soc., 2000
12.
97Ru-transferrin uptake in tumor and abscess
Som P., Oster Z.H., Matsui K., Guglielmi G., Persson B.R., Pellettieri M.L., Srivastava S.C., Richards P., Atkins H.L., Brill A.B.
European Journal of Nuclear Medicine and Molecular Imaging, 1983
13.
A new method for separation of 97Ru from irradiated by α-particles molybdenum for nuclear medicine
Kazakov A.G., Ivanov I.A., Orlova M.A., Priselkova A.B., Aliev R.A., Aleshin G.Y., Trofimova T.P., Kalmykov S.N.
Russian Chemical Bulletin, 2020
14.
Drug development: Lessons from nature
Mathur S., Hoskins C.
Biomedical Reports, 2017
15.
Natural Products as a Foundation for Drug Discovery
Beutler J.A.
Current Protocols in Pharmacology, 2009
16.
Chiral Helicity Induced by Hydrogen Bonding and Chirality of Podand Histidyl Moieties
Moriuchi T., Nishiyama M., Yoshida K., Ishikawa T., Hirao T.
Organic Letters, 2001
18.
Design, Synthesis, and Characterization of Tyrosinophanes, a Novel Family of Aromatic-Bridged Tyrosine-Based Cyclodepsipeptides
Ranganathan D., Thomas A., Haridas V., Kurur S., Madhusudanan K.P., Roy R., Kunwar A.C., Sarma A.V., Vairamani M., Sarma K.D.
Journal of Organic Chemistry, 1999
22.
Novel chiral imidazole cyclophane receptors: synthesis and enantioselective recognition for amino acid derivatives
You J., Yu X., Xiang Q., Lan J., Xie R., Zhang G.
Chemical Communications, 2001
24.
Macrocyclic Compound as NMR Chiral Solvating Agent for Determination of Enantiomeric Excess of Carboxylic Acids
Yang X., Ning R., Xie L., Cui Y., Zhang Y., Zheng L.
Bulletin of the Chemical Society of Japan, 2013
26.
Chromogenic Chemosensors forN-Acetylaspartate Based on Chiral Ferrocene-Bearing Thiourea Derivatives
Qing G., Sun T., Wang F., He Y., Yang X.
European Journal of Organic Chemistry, 2009
29.
Fluoride binding by an anionic receptor: tuning the acidity of amide NH groups for basic anion hydrogen bonding and recognition
Montis R., Bencini A., Coles S.J., Conti L., Fusaro L., Gale P.A., Giorgi C., Horton P.N., Lippolis V., Mapp L.K., Caltagirone C.
Chemical Communications, 2019
30.
Macrocyclic peptidomimetics with antimicrobial activity: synthesis, bioassay, and molecular modeling studies
Ibrahim M.A., Panda S.S., Oliferenko A.A., Oliferenko P.V., Girgis A.S., Elagawany M., Küçükbay F.Z., Panda C.S., Pillai G.G., Samir A., Tämm K., Hall C.D., Katritzky A.R.
Organic and Biomolecular Chemistry, 2015
31.
Synthesis of pseudopeptides based l-tryptophan as a potential antimicrobial agent
Lv J., Yin L., Liu T., Wang Y.
Bioorganic and Medicinal Chemistry Letters, 2007
33.
10.1016/j.mencom.2021.03.020_sbref0075b
Abo-Ghalia
B: J. Chem. Sci., 2003
35.
Sensitization of hyperthermic treatment of leukemic cell lines by a synthetic peptide
Hori Y., Nagai R., Urabe N., Yoshikawa T., Otsuka M.
Bioorganic and Medicinal Chemistry, 2002
36.
An Artificial CuII complex with intriguing oxygen radical-quenching profile. X-ray structure, cytochrome C assay, and ESR study
Otsuka M., Satake H., Murakami S., Doi M., Ishida T., Shibasaki M., Sugiura Y.
Bioorganic and Medicinal Chemistry, 1996
37.
Synthesis, characterization, and spectroscopic properties of three novel pentadentate copper(II) complexes related to the metal-chelating inhibitors against DNA binding with HIV-EP1
Kurosaki H., Sharma R.K., Aoki S., Inoue T., Okamoto Y., Sugiura Y., Doi M., Ishida T., Otsuka M., Goto M.
Journal of the Chemical Society Dalton Transactions, 2001
39.
Novel Zinc Chelators with Dual Activity in the Inhibition of the .kappa.B Site-Binding Proteins, HIV-EP1 and NF-.kappa.B
Otsuka M., Fujita M., Aoki T., Ishii S., Sugiura Y., Yamamoto T., Inoue J.
Journal of Medicinal Chemistry, 1995
40.
Novel Zinc Chelators Which Inhibit the Binding of HIV-EP1 (HIV Enhancer Binding Protein) to NF-.kappa.B Recognition Sequence
Otsuka M., Fujita M., Sugiura Y., Ishii S., Aoki T., Yamamoto T., Inoue J.
Journal of Medicinal Chemistry, 1994
41.
Zakirova G.G., Matveev P.I., Mladentsev D.Y., Evsiunina M.V., Tafeenko V.A., Borisova N.E.
Mendeleev Communications, 2019
42.
Farat O.K., Kharcheva A.V., Ioutsi V.A., Borisova N.E., Reshetova M.D., Patsaeva S.V.
Mendeleev Communications, 2019
44.
10.1016/j.mencom.2021.03.020_sbref0100b
Paramonova
Radiokhimiya, 1959