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Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids

Sergey Nikolaevich Adamovich 1
Sergey Nikolaevich Adamovich
, 
Evgeny Khasanovich Sadykov 1
Evgeny Khasanovich Sadykov
, 
Igor Alekseevich Ushakov 1
Igor Alekseevich Ushakov
, 
Elizaveta Nikolaevna Oborina 1
Elizaveta Nikolaevna Oborina
, 
Lydmila Aleksandrovna Belovezhets 1
Lydmila Aleksandrovna Belovezhets
10.1016/j.mencom.2021.03.019
Published 2021-03-03
Communication , Volume 31, Issue 2, 204-206
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Adamovich S. N. et al. Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 204-206.
GOST all authors (up to 50) Copy
Adamovich S. N., Sadykov E. K., Ushakov I. A., Oborina E. N., Belovezhets L. A. Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids // Mendeleev Communications. 2021. Vol. 31. No. 2. pp. 204-206.
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TY - JOUR
DO - 10.1016/j.mencom.2021.03.019
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.019
TI - Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids
T2 - Mendeleev Communications
AU - Adamovich, Sergey Nikolaevich
AU - Sadykov, Evgeny Khasanovich
AU - Ushakov, Igor Alekseevich
AU - Oborina, Elizaveta Nikolaevna
AU - Belovezhets, Lydmila Aleksandrovna
PY - 2021
DA - 2021/03/03
PB - Mendeleev Communications
SP - 204-206
IS - 2
VL - 31
ER -
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@article{2021_Adamovich,
author = {Sergey Nikolaevich Adamovich and Evgeny Khasanovich Sadykov and Igor Alekseevich Ushakov and Elizaveta Nikolaevna Oborina and Lydmila Aleksandrovna Belovezhets},
title = {Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.019},
number = {2},
pages = {204--206},
doi = {10.1016/j.mencom.2021.03.019}
}
MLA
Cite this
MLA Copy
Adamovich, Sergey Nikolaevich, et al. “Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids.” Mendeleev Communications, vol. 31, no. 2, Mar. 2021, pp. 204-206. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.03.019.

Keywords

antimicrobial action
antitumor activity
hybrids
pyrrolecarboxamides
silatranes

Abstract

Silatrane-1H-pyrrole-2-carboxamide hybrids conjugated via propane-1,3-diyl linker have been synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-(trichloroacetyl)pyrroles. Their in silico screening would predict their antitumor activity. Their in vitro screening for antimicrobial activity revealed the representative with R1=R2=R3=H to be the most potent against Gram-positive microorganisms such as E. durans, B. subtilis and E. coli.

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