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Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units

Ahmed E.M. Mekky 1
Ahmed E.M. Mekky
, 
Sherif M.H. Sanad 1
Sherif M.H. Sanad
10.1016/j.mencom.2020.11.024
Published 2020-11-03
Communication , Volume 30, Issue 6, 762-764
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Mekky A. E., Sanad S. M. Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 762-764.
GOST all authors (up to 50) Copy
Mekky A. E., Sanad S. M. Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 762-764.
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TY - JOUR
DO - 10.1016/j.mencom.2020.11.024
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.024
TI - Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units
T2 - Mendeleev Communications
AU - Mekky, Ahmed E.M.
AU - Sanad, Sherif M.H.
PY - 2020
DA - 2020/11/03
PB - Mendeleev Communications
SP - 762-764
IS - 6
VL - 30
ER -
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@article{2020_Mekky,
author = {Ahmed E.M. Mekky and Sherif M.H. Sanad},
title = {Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.024},
number = {6},
pages = {762--764},
doi = {10.1016/j.mencom.2020.11.024}
}
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Mekky, Ahmed E.M., and Sherif M.H. Sanad. “Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units.” Mendeleev Communications, vol. 30, no. 6, Nov. 2020, pp. 762-764. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.024.

Keywords

2H-chromen-2-imines
Antibacterial activity
benzo[f]chromen-3-imines
heterocyclization
hybrid molecules
Knoevenagel reaction
nitriles
salicylic aldehydes

Abstract

Novel mono- and bis(2H-chromen-2-imine) hybrids linked to different heteroarene units were prepared by cyclocondensation of 2-hydroxybenzaldehydes with 2-heteroarylacetonitriles. Their in vitro antibacterial activities against different strains of Gram-positive and negative bacteria were assessed. Piperazine-linked bis(3-heteroaryl-2Hchromen-2-imines) exhibited the best antibacterial efficacies against E. coli, S. aureus and S. mutans strains with MIC values of 1.4–20.8μm.

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