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Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

Linh M Nguyen 1, 2
Linh M Nguyen
, 
Hieu Hong Truong 3
Hieu Hong Truong
, 
Victor Nikolaevich Khrustalev 3, 4
Victor Nikolaevich Khrustalev
, 
Sang T Truong 1
Sang T Truong
, 
Dat T Nguyen 1
Dat T Nguyen
, 
Van T.T. Tran 1
Van T.T. Tran
, 
Son T Mai 1
Son T Mai
, 
Van T Tran 1
Van T Tran
, 
Anh Tuan Le 1
Anh Tuan Le
10.1016/j.mencom.2020.11.021
Published 2020-11-03
Communication , Volume 30, Issue 6, 753-755
6
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Nguyen L. M. et al. Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 753-755.
GOST all authors (up to 50) Copy
Nguyen L. M., Truong H. H., Khrustalev V. N., Truong S. T., Nguyen D. T., Tran V. T., Mai S. T., Tran V. T., Le A. T. Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 753-755.
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TY - JOUR
DO - 10.1016/j.mencom.2020.11.021
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.021
TI - Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings
T2 - Mendeleev Communications
AU - Nguyen, Linh M
AU - Truong, Hieu Hong
AU - Khrustalev, Victor Nikolaevich
AU - Truong, Sang T
AU - Nguyen, Dat T
AU - Tran, Van T.T.
AU - Mai, Son T
AU - Tran, Van T
AU - Le, Anh Tuan
PY - 2020
DA - 2020/11/03
PB - Mendeleev Communications
SP - 753-755
IS - 6
VL - 30
ER -
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@article{2020_Nguyen,
author = {Linh M Nguyen and Hieu Hong Truong and Victor Nikolaevich Khrustalev and Sang T Truong and Dat T Nguyen and Van T.T. Tran and Son T Mai and Van T Tran and Anh Tuan Le},
title = {Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.021},
number = {6},
pages = {753--755},
doi = {10.1016/j.mencom.2020.11.021}
}
MLA
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MLA Copy
Nguyen, Linh M., et al. “Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings.” Mendeleev Communications, vol. 30, no. 6, Nov. 2020, pp. 753-755. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.021.

Keywords

antimicrobial
cytotoxicity
diazacrownophane
domino condensation
pyridine
γ-piperidone

Abstract

Six novel phane-structured diazacrowns containing γ-piperidone and pyridine rings were synthesized from podand 2-+,6-bis(2-formylphenoxymethyl)pyridine, with the γ-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration.

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