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A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells

Sergey Aleksandrovich Gorbatov 1, 2
Sergey Aleksandrovich Gorbatov
, 
Denis Yuryevich Uvarov 1
Denis Yuryevich Uvarov
, 
Alexander Mikhailovich Scherbakov 3
Alexander Mikhailovich Scherbakov
, 
Igor Viktorovich Zavarzin 1
Igor Viktorovich Zavarzin
, 
Yulia Alekseevna Volkova 1
Yulia Alekseevna Volkova
, 
Anthony Romieu 2
Anthony Romieu
10.1016/j.mencom.2020.11.020
Published 2020-11-03
Communication , Volume 30, Issue 6, 750-752
5
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Gorbatov S. A. et al. A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 750-752.
GOST all authors (up to 50) Copy
Gorbatov S. A., Uvarov D. Y., Scherbakov A. M., Zavarzin I. V., Volkova Y. A., Romieu A. A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells // Mendeleev Communications. 2020. Vol. 30. No. 6. pp. 750-752.
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TY - JOUR
DO - 10.1016/j.mencom.2020.11.020
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.020
TI - A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells
T2 - Mendeleev Communications
AU - Gorbatov, Sergey Aleksandrovich
AU - Uvarov, Denis Yuryevich
AU - Scherbakov, Alexander Mikhailovich
AU - Zavarzin, Igor Viktorovich
AU - Volkova, Yulia Alekseevna
AU - Romieu, Anthony
PY - 2020
DA - 2020/11/03
PB - Mendeleev Communications
SP - 750-752
IS - 6
VL - 30
ER -
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@article{2020_Gorbatov,
author = {Sergey Aleksandrovich Gorbatov and Denis Yuryevich Uvarov and Alexander Mikhailovich Scherbakov and Igor Viktorovich Zavarzin and Yulia Alekseevna Volkova and Anthony Romieu},
title = {A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.020},
number = {6},
pages = {750--752},
doi = {10.1016/j.mencom.2020.11.020}
}
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Gorbatov, Sergey Aleksandrovich, et al. “A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells.” Mendeleev Communications, vol. 30, no. 6, Nov. 2020, pp. 750-752. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.11.020.

Keywords

BODIPY
fluorescent probe
hypoxia
lung cancer
nitroreductase

Abstract

The development of effective methods for real-time monitoring of nitroreductase (NTR) activity is of great significance for medical diagnosis and cancer research. Here, we present a novel water-soluble BODIPY-based chemodosimeter (NBB) for imaging the hypoxic status of human non-small-cell lung cancer A549 cells. We assume that ‘on–off’ response of NBB is activated by the NTRmediated reductive release of meso-phenol BODIPY dye resulting in unusual fluorescence.

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