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New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity

Maria Petrovna Paramonova 1
Maria Petrovna Paramonova
, 
Robert Snoeck 2
Robert Snoeck
, 
Graciela Andrei 2
Graciela Andrei
, 
Anastasia Lvovna Khandazhinskaya 3
Anastasia Lvovna Khandazhinskaya
, 
Mikhail Stanislavovich Novikov 1
Mikhail Stanislavovich Novikov
10.1016/j.mencom.2020.09.016
Published 2020-08-31
Communication , Volume 30, Issue 5, 602-603
9
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Paramonova M. P. et al. New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 602-603.
GOST all authors (up to 50) Copy
Paramonova M. P., Snoeck R., Andrei G., Khandazhinskaya A. L., Novikov M. S. New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity // Mendeleev Communications. 2020. Vol. 30. No. 5. pp. 602-603.
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TY - JOUR
DO - 10.1016/j.mencom.2020.09.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.09.016
TI - New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity
T2 - Mendeleev Communications
AU - Paramonova, Maria Petrovna
AU - Snoeck, Robert
AU - Andrei, Graciela
AU - Khandazhinskaya, Anastasia Lvovna
AU - Novikov, Mikhail Stanislavovich
PY - 2020
DA - 2020/08/31
PB - Mendeleev Communications
SP - 602-603
IS - 5
VL - 30
ER -
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@article{2020_Paramonova,
author = {Maria Petrovna Paramonova and Robert Snoeck and Graciela Andrei and Anastasia Lvovna Khandazhinskaya and Mikhail Stanislavovich Novikov},
title = {New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Aug},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.09.016},
number = {5},
pages = {602--603},
doi = {10.1016/j.mencom.2020.09.016}
}
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Paramonova, Maria Petrovna, et al. “New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity.” Mendeleev Communications, vol. 30, no. 5, Aug. 2020, pp. 602-603. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.09.016.

Keywords

acetamide
antiviral activity
bromoarene
diaryl oxide
human cytomegalovirus
uracil derivative

Abstract

New N-aryl-2-{3-[ω-(4-bromophenoxy)alkyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}acetamides have been obtained from 1-[ω-(4-bromophenoxy)alkyl]uracil and 2-chloro-N-(4-phenoxyphenyl)acetamide derivatives. Investigation of their antiviral properties against human cytomegalovirus revealed that the representative with dodecane-1,12-diyl linker exhibited powerful virus inhibitory activity in vitro.

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