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Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer

Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
, 
Nikita Andreevich Frolov 1
Nikita Andreevich Frolov
, 
Valeria Yuryevna Konyuhova 1
Valeria Yuryevna Konyuhova
, 
Evgeniya Olegovna Dorofeeva 1
Evgeniya Olegovna Dorofeeva
, 
Karl A Hansford 2
Karl A Hansford
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.1016/j.mencom.2020.07.006
Published 2020-06-26
Communication , Volume 30, Issue 4, 424-426
19
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Vereshchagin A. N. et al. Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer // Mendeleev Communications. 2020. Vol. 30. No. 4. pp. 424-426.
GOST all authors (up to 50) Copy
Vereshchagin A. N., Frolov N. A., Konyuhova V. Y., Dorofeeva E. O., Hansford K. A., Egorov M. P. Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer // Mendeleev Communications. 2020. Vol. 30. No. 4. pp. 424-426.
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TY - JOUR
DO - 10.1016/j.mencom.2020.07.006
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.006
TI - Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer
T2 - Mendeleev Communications
AU - Vereshchagin, Anatoly Nikolaevich
AU - Frolov, Nikita Andreevich
AU - Konyuhova, Valeria Yuryevna
AU - Dorofeeva, Evgeniya Olegovna
AU - Hansford, Karl A
AU - Egorov, Mikhail Petrovich
PY - 2020
DA - 2020/06/26
PB - Mendeleev Communications
SP - 424-426
IS - 4
VL - 30
ER -
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@article{2020_Vereshchagin,
author = {Anatoly Nikolaevich Vereshchagin and Nikita Andreevich Frolov and Valeria Yuryevna Konyuhova and Evgeniya Olegovna Dorofeeva and Karl A Hansford and Mikhail Petrovich Egorov},
title = {Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.006},
number = {4},
pages = {424--426},
doi = {10.1016/j.mencom.2020.07.006}
}
MLA
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MLA Copy
Vereshchagin, Anatoly Nikolaevich, et al. “Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer.” Mendeleev Communications, vol. 30, no. 4, Jun. 2020, pp. 424-426. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.006.

Keywords

Staphylococcus aureus
alkylation
antibacterial agents
Antifungal activity
bis-quaternary ammonium compounds
fungicides
methicillin resistance
pyridinium salts
terphenyls

Abstract

Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C8H17 aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.

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