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Temperature cycle induced deracemization

Kritsada Intaraboonrod 1
Kritsada Intaraboonrod
, 
Tharit Lerdwiriyanupap 2
Tharit Lerdwiriyanupap
, 
Marine Hoquante 3
Marine Hoquante
, 
Gerard Coquerel 3
Gerard Coquerel
, 
Adrian E Flood 1
Adrian E Flood
10.1016/j.mencom.2020.07.002
Published 2020-06-26
Focus article , Volume 30, Issue 4, 395-405
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Intaraboonrod K. et al. Temperature cycle induced deracemization // Mendeleev Communications. 2020. Vol. 30. No. 4. pp. 395-405.
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Intaraboonrod K., Lerdwiriyanupap T., Hoquante M., Coquerel G., Flood A. E. Temperature cycle induced deracemization // Mendeleev Communications. 2020. Vol. 30. No. 4. pp. 395-405.
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TY - JOUR
DO - 10.1016/j.mencom.2020.07.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.002
TI - Temperature cycle induced deracemization
T2 - Mendeleev Communications
AU - Intaraboonrod, Kritsada
AU - Lerdwiriyanupap, Tharit
AU - Hoquante, Marine
AU - Coquerel, Gerard
AU - Flood, Adrian E
PY - 2020
DA - 2020/06/26
PB - Mendeleev Communications
SP - 395-405
IS - 4
VL - 30
ER -
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@article{2020_Intaraboonrod,
author = {Kritsada Intaraboonrod and Tharit Lerdwiriyanupap and Marine Hoquante and Gerard Coquerel and Adrian E Flood},
title = {Temperature cycle induced deracemization},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.002},
number = {4},
pages = {395--405},
doi = {10.1016/j.mencom.2020.07.002}
}
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Intaraboonrod, Kritsada, et al. “Temperature cycle induced deracemization.” Mendeleev Communications, vol. 30, no. 4, Jun. 2020, pp. 395-405. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.07.002.
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Keywords

chirality
deracemization
enantiopurification
optical resolution
racemization
temperature cycle

Abstract

The problem of separation and purification of the enantiomers of chiral species is a significant issue in the production of modern chemicals of pharmaceutical, agricultural and food industries. Efficient methods enabling a complete conversion of a racemic mixture into the desired enantiomer would be of great benefit to industry. Temperature cycle induced deracemization (TCID), a process allowing an initially racemic crystal phase of a suspension to be converted into an enantiopure state, combines solution phase racemization of the solute molecules and a series of temperature cycles inducing dissolution and crystal growth. The process first described as a more convenient and scalable alternative to Viedma ripening, has now been successfully tested on a wide range of chiral components that are conglomerate forming and racemizable. This review discusses the origins of TCID, potential mechanisms responsible for the deracemization, and also some related processes.

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