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Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles

Lyudmila Alexandrovna Sviridova 1
Lyudmila Alexandrovna Sviridova
, 
Polina Sergeevna Protopopova 2
Polina Sergeevna Protopopova
, 
Mikhail Genadievich Akimov 3
Mikhail Genadievich Akimov
, 
Maria Sergeevna Dudina 3
Maria Sergeevna Dudina
, 
Elizaveta Konstantinovna Melnikova 1, 2
Elizaveta Konstantinovna Melnikova
, 
Konstantin Aleksandrovich Kochetkov 2, 4
Konstantin Aleksandrovich Kochetkov
10.1016/j.mencom.2020.05.029
Published 2020-04-30
Communication , Volume 30, Issue 3, 347-349
6
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Sviridova L. A. et al. Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles // Mendeleev Communications. 2020. Vol. 30. No. 3. pp. 347-349.
GOST all authors (up to 50) Copy
Sviridova L. A., Protopopova P. S., Akimov M. G., Dudina M. S., Melnikova E. K., Kochetkov K. A. Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles // Mendeleev Communications. 2020. Vol. 30. No. 3. pp. 347-349.
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TY - JOUR
DO - 10.1016/j.mencom.2020.05.029
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.029
TI - Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles
T2 - Mendeleev Communications
AU - Sviridova, Lyudmila Alexandrovna
AU - Protopopova, Polina Sergeevna
AU - Akimov, Mikhail Genadievich
AU - Dudina, Maria Sergeevna
AU - Melnikova, Elizaveta Konstantinovna
AU - Kochetkov, Konstantin Aleksandrovich
PY - 2020
DA - 2020/04/30
PB - Mendeleev Communications
SP - 347-349
IS - 3
VL - 30
ER -
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@article{2020_Sviridova,
author = {Lyudmila Alexandrovna Sviridova and Polina Sergeevna Protopopova and Mikhail Genadievich Akimov and Maria Sergeevna Dudina and Elizaveta Konstantinovna Melnikova and Konstantin Aleksandrovich Kochetkov},
title = {Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.029},
number = {3},
pages = {347--349},
doi = {10.1016/j.mencom.2020.05.029}
}
MLA
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MLA Copy
Sviridova, Lyudmila Alexandrovna, et al. “Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles.” Mendeleev Communications, vol. 30, no. 3, Apr. 2020, pp. 347-349. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.029.

Keywords

3- or 2-(2-oxoimidazolidin-5-yl)indoles
amidoalkylation
anti-inflammatory activity
biheterocycles
imidazolylindoles
indoles

Abstract

Boron trifluoride-catalyzed amidoalkylation of indole derivatives with 5-hydroxy-1-phenylimidozolidin-2-one affords new biheterocycles with a direct C–C bond. Among them, 3- or 2-(2-oxoimidazolidin-5-yl)indoles manifest antiinflammatory activity with relatively low toxicity.

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