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Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines

Gulnara Nazifovna Kadikova 1
Gulnara Nazifovna Kadikova
, 
Vladimir Anatol'evich D'yakonov 1
Vladimir Anatol'evich D'yakonov
, 
Ramil Nurfaizovich Nasretdinov 1
Ramil Nurfaizovich Nasretdinov
, 
Lilya Useinovna Dzhemileva 1
Lilya Useinovna Dzhemileva
, 
10.1016/j.mencom.2020.05.019
Published 2020-04-30
Communication , Volume 30, Issue 3, 318-319
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Kadikova G. N. et al. Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines // Mendeleev Communications. 2020. Vol. 30. No. 3. pp. 318-319.
GOST all authors (up to 50) Copy
Kadikova G. N., D'yakonov V. A., Nasretdinov R. N., Dzhemileva L. U., Dzhemilev U. M. Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines // Mendeleev Communications. 2020. Vol. 30. No. 3. pp. 318-319.
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TY - JOUR
DO - 10.1016/j.mencom.2020.05.019
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.019
TI - Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines
T2 - Mendeleev Communications
AU - Kadikova, Gulnara Nazifovna
AU - D'yakonov, Vladimir Anatol'evich
AU - Nasretdinov, Ramil Nurfaizovich
AU - Dzhemileva, Lilya Useinovna
AU - Dzhemilev, Usein Memetovich
PY - 2020
DA - 2020/04/30
PB - Mendeleev Communications
SP - 318-319
IS - 3
VL - 30
ER -
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@article{2020_Kadikova,
author = {Gulnara Nazifovna Kadikova and Vladimir Anatol'evich D'yakonov and Ramil Nurfaizovich Nasretdinov and Lilya Useinovna Dzhemileva and Usein Memetovich Dzhemilev},
title = {Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.019},
number = {3},
pages = {318--319},
doi = {10.1016/j.mencom.2020.05.019}
}
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Kadikova, Gulnara Nazifovna, et al. “Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines.” Mendeleev Communications, vol. 30, no. 3, Apr. 2020, pp. 318-319. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.019.

Keywords

1,3-diynes
9-azabicyclo[4.2.1]nona-2,4,7-trienes
antitumor activity
azepine-1-carboxylates
catalytic systems
cobalt complexes
cycloaddition

Abstract

New 7-alkynyl-9-azabicyclo[4.2.1]nona-2,4,7-triene-9carboxylates were obtained upon the Co(acac)2(dppe)/Zn/ZnI2catalyzed [6p+2p]-cycloaddition of 1,3-diynes to ethyl/phenyl azepine-1-carboxylates. The structures of the obtained azacyclic compounds were established by 1D and 2D NMR spectroscopy. The compounds prepared were tested for antitumor activities in vitro against Jurkat, K562, U937 and HL60 cancer cell lines.

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