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9H-Thioxanthen-9-one S,S-dioxide based redox active labels for electrochemical detection of DNA duplexes immobilized on Au electrodes

Leonid Anatol'evich Shundrin 1
Leonid Anatol'evich Shundrin
, 
Irina Aleksandrovna Os'kina 1
Irina Aleksandrovna Os'kina
, 
Irina Gennad'evna Irtegova 1
Irina Gennad'evna Irtegova
, 
Alexandr F Poveshchenko 2
Alexandr F Poveshchenko
10.1016/j.mencom.2020.05.011
Published 2020-04-30
Communication , Volume 30, Issue 3, 296-298
3
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Shundrin L. A. et al. 9H-Thioxanthen-9-one S,S-dioxide based redox active labels for electrochemical detection of DNA duplexes immobilized on Au electrodes // Mendeleev Communications. 2020. Vol. 30. No. 3. pp. 296-298.
GOST all authors (up to 50) Copy
Shundrin L. A., Os'kina I. A., Irtegova I. G., Poveshchenko A. F. 9H-Thioxanthen-9-one S,S-dioxide based redox active labels for electrochemical detection of DNA duplexes immobilized on Au electrodes // Mendeleev Communications. 2020. Vol. 30. No. 3. pp. 296-298.
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TY - JOUR
DO - 10.1016/j.mencom.2020.05.011
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.011
TI - 9H-Thioxanthen-9-one S,S-dioxide based redox active labels for electrochemical detection of DNA duplexes immobilized on Au electrodes
T2 - Mendeleev Communications
AU - Shundrin, Leonid Anatol'evich
AU - Os'kina, Irina Aleksandrovna
AU - Irtegova, Irina Gennad'evna
AU - Poveshchenko, Alexandr F
PY - 2020
DA - 2020/04/30
PB - Mendeleev Communications
SP - 296-298
IS - 3
VL - 30
ER -
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@article{2020_Shundrin,
author = {Leonid Anatol'evich Shundrin and Irina Aleksandrovna Os'kina and Irina Gennad'evna Irtegova and Alexandr F Poveshchenko},
title = {9H-Thioxanthen-9-one S,S-dioxide based redox active labels for electrochemical detection of DNA duplexes immobilized on Au electrodes},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.011},
number = {3},
pages = {296--298},
doi = {10.1016/j.mencom.2020.05.011}
}
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Shundrin, Leonid Anatol'evich, et al. “9H-Thioxanthen-9-one S,S-dioxide based redox active labels for electrochemical detection of DNA duplexes immobilized on Au electrodes.” Mendeleev Communications, vol. 30, no. 3, Apr. 2020, pp. 296-298. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.05.011.

Keywords

cyclic voltammetry
electrochemical genosensors
electrochemical reduction
modified oligonucleotides
redox active labels
thioxanthen-9-ones

Abstract

The reaction of 2-bromomethyl-9H-thioxanthen-9-one with 2-/4-mercaptobenzoic acids led to 2-/4-[(9-oxo-9H-thioxanthen-2-yl)methylthio]benzoic acids. Their further oxidation by H2O2 gave the corresponding S,S-dioxides, which were used as redox active modifiers for a model oligonucleotide. Hybridization of the modified oligonucleotide with a complementary oligoprobe immobilized on Au electrode led to formation of the corresponding redox active DNA duplex, which was reliably detected by cyclic voltammetry.

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