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TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac

Alexander Yur'evich Gorbunov 1, 2
Alexander Yur'evich Gorbunov
, 
Konstantin Andreevich Krasnov 3
Konstantin Andreevich Krasnov
, 
Alexander Aleksandrovich Bardin 1
Alexander Aleksandrovich Bardin
, 
Olga Alexandrovna Keltsieva 2, 3
Olga Alexandrovna Keltsieva
, 
Vladimir Nikolaevich Babakov 1
Vladimir Nikolaevich Babakov
, 
Ekaterina Petrovna Podolskaya 2, 3
Ekaterina Petrovna Podolskaya
1 Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
3 Institute of Toxicology, St. Petersburg, Russian Federation
10.1016/j.mencom.2020.03.030
Published 2020-03-02
Communication , Volume 30, Issue 2, 220-222
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Gorbunov A. Y. et al. TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 220-222.
GOST all authors (up to 50) Copy
Gorbunov A. Y., Krasnov K. A., Bardin A. A., Keltsieva O. A., Babakov V. N., Podolskaya E. P. TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 220-222.
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TY - JOUR
DO - 10.1016/j.mencom.2020.03.030
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.030
TI - TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac
T2 - Mendeleev Communications
AU - Gorbunov, Alexander Yur'evich
AU - Krasnov, Konstantin Andreevich
AU - Bardin, Alexander Aleksandrovich
AU - Keltsieva, Olga Alexandrovna
AU - Babakov, Vladimir Nikolaevich
AU - Podolskaya, Ekaterina Petrovna
PY - 2020
DA - 2020/03/02
PB - Mendeleev Communications
SP - 220-222
IS - 2
VL - 30
ER -
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@article{2020_Gorbunov,
author = {Alexander Yur'evich Gorbunov and Konstantin Andreevich Krasnov and Alexander Aleksandrovich Bardin and Olga Alexandrovna Keltsieva and Vladimir Nikolaevich Babakov and Ekaterina Petrovna Podolskaya},
title = {TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.030},
number = {2},
pages = {220--222},
doi = {10.1016/j.mencom.2020.03.030}
}
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Gorbunov, Alexander Yur'evich, et al. “TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac.” Mendeleev Communications, vol. 30, no. 2, Mar. 2020, pp. 220-222. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.030.

Keywords

drug metabolites
MALDI MS
photocatalysis
photooxidation
titanium dioxide

Abstract

The UV-induced photocatalytic oxidation in the presence of TiO2 nanoparticles (UV/TiO2-PCO) is a more adequate approach than electrochemical oxidation to simulate the oxidative metabolism of diclofenac based on the comparative analysis of oxidation products using high-resolution tandem mass spectrometry. A simple and fast high-throughput technique is proposed for modeling the oxidative metabolism, which involves UV/TiO2-PCO performed directly on a MALDI target and subsequent analysis by matrix-assisted laser desorption/ionization mass spectrometry. The ranges and yields of diclofenac oxidation products obtained by the conventional bulk UV/TiO2-PCO and the proposed on-target version are in excellent agreement.

References

1.
Managing the challenge of chemically reactive metabolites in drug development
Park B.K., Boobis A., Clarke S., Goldring C.E., Jones D., Kenna J.G., Lambert C., Laverty H.G., Naisbitt D.J., Nelson S., Nicoll-Griffith D.A., Obach R.S., Routledge P., Smith D.A., Tweedie D.J., et. al.
Nature Reviews Drug Discovery, 2011
2.
Biomimetic modeling of oxidative drug metabolism
Lohmann W., Karst U.
Analytical and Bioanalytical Chemistry, 2007
3.
10.1016/j.mencom.2020.03.030_bib0015
Tong
Cent. Eur. J. Chem., 2012
4.
Kovalev I.A., Petrov A.A., Ibragimova O.A., Shokod’ko A.V., Chernyavskii A.S., Goodilin E.A., Solntseva K.A., Tarasov A.B.
Mendeleev Communications, 2018
7.
Comparison of TiO2 photocatalysis, electrochemically assisted Fenton reaction and direct electrochemistry for simulation of phase I metabolism reactions of drugs
Ruokolainen M., Gul T., Permentier H., Sikanen T., Kostiainen R., Kotiaho T.
European Journal of Pharmaceutical Sciences, 2016
8.
Imitation of phase I metabolism reactions of MAO-A inhibitors by titanium dioxide photocatalysis
Gawlik M., Trawiński J., Skibiński R.
European Journal of Pharmaceutical Sciences, 2018
9.
Integrated photocatalytic micropillar nanoreactor electrospray ionization chip for mimicking phase I metabolic reactions
Nissilä T., Sainiemi L., Karikko M., Kemell M., Ritala M., Franssila S., Kostiainen R., Ketola R.A.
Lab on a Chip, 2011
10.
TiO2 Photocatalysis–DESI-MS Rotating Array Platform for High-Throughput Investigation of Oxidation Reactions
Ruokolainen M., Miikkulainen V., Ritala M., Sikanen T., Kotiaho T., Kostiainen R.
Analytical Chemistry, 2017
11.
TiO2 Photocatalyzed Oxidation of Drugs Studied by Laser Ablation Electrospray Ionization Mass Spectrometry
van Geenen F.A., Franssen M.C., Miikkulainen V., Ritala M., Zuilhof H., Kostiainen R., Nielen M.W.
Journal of the American Society for Mass Spectrometry, 2019
12.
Photocatalytic degradation study of diclofenac over aqueous TiO2 suspensions
Calza P., Sakkas V.A., Medana C., Baiocchi C., Dimou A., Pelizzetti E., Albanis T.
Applied Catalysis B: Environmental, 2006
14.
Biotransformation of diclofenac sodium (Voltaren®) in animals and in man
Stierlin H., Faigle J.W., Sallmann A., Kung W., Richter W.J., Kriemler H.-., Alt K.O., Winkler T.
Xenobiotica, 1979
15.
10.1002/(SICI)1096-9888(200003)35:3<417::AID-JMS952>3.0.CO;2-#
16.
Surface-assisted laser desorption/ionization-mass spectrometry using TiO2-coated steel targets for the analysis of small molecules
Sonderegger H., Rameshan C., Lorenz H., Klauser F., Klerks M., Rainer M., Bakry R., Huck C.W., Bonn G.K.
Analytical and Bioanalytical Chemistry, 2011
17.
MALDI matrices for low molecular weight compounds: an endless story?
Calvano C.D., Monopoli A., Cataldi T.R., Palmisano F.
Analytical and Bioanalytical Chemistry, 2018