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Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation

Elena Vladimirovna Sadchikova 1, 2
Elena Vladimirovna Sadchikova
, 
Daria Leonidovna Alexeeva 1
Daria Leonidovna Alexeeva
, 
Valentin Georgievich Nenajdenko 3
Valentin Georgievich Nenajdenko
10.1016/j.mencom.2020.03.016
Published 2020-03-02
Communication , Volume 30, Issue 2, 180-182
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Sadchikova E. V., Alexeeva D. L., Nenajdenko V. G. Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 180-182.
GOST all authors (up to 50) Copy
Sadchikova E. V., Alexeeva D. L., Nenajdenko V. G. Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 180-182.
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TY - JOUR
DO - 10.1016/j.mencom.2020.03.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.016
TI - Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation
T2 - Mendeleev Communications
AU - Sadchikova, Elena Vladimirovna
AU - Alexeeva, Daria Leonidovna
AU - Nenajdenko, Valentin Georgievich
PY - 2020
DA - 2020/03/02
PB - Mendeleev Communications
SP - 180-182
IS - 2
VL - 30
ER -
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@article{2020_Sadchikova,
author = {Elena Vladimirovna Sadchikova and Daria Leonidovna Alexeeva and Valentin Georgievich Nenajdenko},
title = {Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.016},
number = {2},
pages = {180--182},
doi = {10.1016/j.mencom.2020.03.016}
}
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Sadchikova, Elena Vladimirovna, et al. “Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation.” Mendeleev Communications, vol. 30, no. 2, Mar. 2020, pp. 180-182. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.016.

Keywords

diazo compounds
diazonium salts
enones
pyrazoles
pyrazolo[5,1-c][1,2,4]triazines
trifluoromethyl group

Abstract

The reaction of 4-dimethylamino-1,1,1-trifluorobut-3-en-2one with 3-arylpyrazole-5-diazonium salt in MeCN affords 7-aryl-3-(trifluoroacetyl)pyrazolo[5,1-c][1,2,4]triazines. The transformation of relative 5-diazopyrazoles leads to 4-hydroxy-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine derivatives, while the reaction in acidic aqueous solution results in 4,4,4-trifluoro-3-oxo-2-(pyrazol-5-ylhydrazono)butanals.

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