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Synthesis of an allosteric modulator of ionotropic glutamate receptors

Mstislav Igorevich Lavrov 1, 2
Mstislav Igorevich Lavrov
, 
Oleg Valentinovich Stroganov 3, 4
Oleg Valentinovich Stroganov
, 
Vladimir Lollievich Zamoyski 2
Vladimir Lollievich Zamoyski
, 
Vladimir Viktorovich Grigoriev 1, 2
Vladimir Viktorovich Grigoriev
, 
Maxim Èduardovich Zapolskiy 4
Maxim Èduardovich Zapolskiy
, 
Sergey Viktorovich Sysolyatin 5
Sergey Viktorovich Sysolyatin
, 
Valeriy Viktorovich Malykhin 5
Valeriy Viktorovich Malykhin
, 
Vladimir Nikolaevich Surmachev 5
Vladimir Nikolaevich Surmachev
, 
Vladimir Alexandrovich Palyulin 1, 2
Vladimir Alexandrovich Palyulin
10.1016/j.mencom.2020.03.008
Published 2020-03-02
Communication , Volume 30, Issue 2, 156-158
7
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Lavrov M. I. et al. Synthesis of an allosteric modulator of ionotropic glutamate receptors // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 156-158.
GOST all authors (up to 50) Copy
Lavrov M. I., Stroganov O. V., Zamoyski V. L., Grigoriev V. V., Zapolskiy M. È., Sysolyatin S. V., Malykhin V. V., Surmachev V. N., Palyulin V. A. Synthesis of an allosteric modulator of ionotropic glutamate receptors // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 156-158.
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TY - JOUR
DO - 10.1016/j.mencom.2020.03.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.008
TI - Synthesis of an allosteric modulator of ionotropic glutamate receptors
T2 - Mendeleev Communications
AU - Lavrov, Mstislav Igorevich
AU - Stroganov, Oleg Valentinovich
AU - Zamoyski, Vladimir Lollievich
AU - Grigoriev, Vladimir Viktorovich
AU - Zapolskiy, Maxim Èduardovich
AU - Sysolyatin, Sergey Viktorovich
AU - Malykhin, Valeriy Viktorovich
AU - Surmachev, Vladimir Nikolaevich
AU - Palyulin, Vladimir Alexandrovich
PY - 2020
DA - 2020/03/02
PB - Mendeleev Communications
SP - 156-158
IS - 2
VL - 30
ER -
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@article{2020_Lavrov,
author = {Mstislav Igorevich Lavrov and Oleg Valentinovich Stroganov and Vladimir Lollievich Zamoyski and Vladimir Viktorovich Grigoriev and Maxim Èduardovich Zapolskiy and Sergey Viktorovich Sysolyatin and Valeriy Viktorovich Malykhin and Vladimir Nikolaevich Surmachev and Vladimir Alexandrovich Palyulin},
title = {Synthesis of an allosteric modulator of ionotropic glutamate receptors},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.008},
number = {2},
pages = {156--158},
doi = {10.1016/j.mencom.2020.03.008}
}
MLA
Cite this
MLA Copy
Lavrov, Mstislav Igorevich, et al. “Synthesis of an allosteric modulator of ionotropic glutamate receptors.” Mendeleev Communications, vol. 30, no. 2, Mar. 2020, pp. 156-158. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.008.

Keywords

3,7-diazabicyclo[3.3.1]nonane
AMPA receptor
NAM
negative allosteric modulator
patch clamp

Abstract

Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10−11 to 10−6m.

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