Home / Publications / Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity

Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity

Antonida Vladimirovna Kalistratova 1
Antonida Vladimirovna Kalistratova
, 
Leonid Vladimirovich Kovalenko 1
Leonid Vladimirovich Kovalenko
, 
Maxim Sergeevich Oshchepkov 1
Maxim Sergeevich Oshchepkov
, 
Alina Mukhadinovna Gamisoniya 2
Alina Mukhadinovna Gamisoniya
, 
Tatiana Sergeevna Gerasimova 1
Tatiana Sergeevna Gerasimova
, 
Yuri A Demidov 1
Yuri A Demidov
, 
Mikhail Genadievich Akimov 2
Mikhail Genadievich Akimov
10.1016/j.mencom.2020.03.007
Published 2020-03-02
Communication , Volume 30, Issue 2, 153-155
9
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Kalistratova A. V. et al. Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 153-155.
GOST all authors (up to 50) Copy
Kalistratova A. V., Kovalenko L. V., Oshchepkov M. S., Gamisoniya A. M., Gerasimova T. S., Demidov Y. A., Akimov M. G. Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity // Mendeleev Communications. 2020. Vol. 30. No. 2. pp. 153-155.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2020.03.007
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.007
TI - Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity
T2 - Mendeleev Communications
AU - Kalistratova, Antonida Vladimirovna
AU - Kovalenko, Leonid Vladimirovich
AU - Oshchepkov, Maxim Sergeevich
AU - Gamisoniya, Alina Mukhadinovna
AU - Gerasimova, Tatiana Sergeevna
AU - Demidov, Yuri A
AU - Akimov, Mikhail Genadievich
PY - 2020
DA - 2020/03/02
PB - Mendeleev Communications
SP - 153-155
IS - 2
VL - 30
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Kalistratova,
author = {Antonida Vladimirovna Kalistratova and Leonid Vladimirovich Kovalenko and Maxim Sergeevich Oshchepkov and Alina Mukhadinovna Gamisoniya and Tatiana Sergeevna Gerasimova and Yuri A Demidov and Mikhail Genadievich Akimov},
title = {Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity},
journal = {Mendeleev Communications},
year = {2020},
volume = {30},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.007},
number = {2},
pages = {153--155},
doi = {10.1016/j.mencom.2020.03.007}
}
MLA
Cite this
MLA Copy
Kalistratova, Antonida Vladimirovna, et al. “Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity.” Mendeleev Communications, vol. 30, no. 2, Mar. 2020, pp. 153-155. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.03.007.

Keywords

anti-stress effect
cytotoxicity
oxidative stress.
substituted ureas
synthetic cytokinins

Abstract

A series of aryl-substituted ureas and carbamates containing chlorinated aromatic and modified imidazolidinone moieties were synthesized. These compounds were found to be cytotoxic to breast cancer cell line MDA-MB-231, glioblastoma U-87 MG and neuroblastoma SH-SY5Y, but not to melanoma A-375.

References

1.
N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1
Laezza C., Caruso M.G., Gentile T., Notarnicola M., Malfitano A.M., Di Matola T., Messa C., Gazzerro P., Bifulco M.
International Journal of Cancer, 2009
2.
10.1016/j.mencom.2020.03.007_bib0010
Kovalenko
Butlerovskie Soobshcheniya, 2017
3.
Genetic engineering of cytokinin metabolism: Prospective way to improve agricultural traits of crop plants
Zalabák D., Pospíšilová H., Šmehilová M., Mrízová K., Frébort I., Galuszka P.
Biotechnology Advances, 2013
4.
Cytokinin activity of N6-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico
Savelieva E.M., Oslovsky V.E., Karlov D.S., Kurochkin N.N., Getman I.A., Lomin S.N., Sidorov G.V., Mikhailov S.N., Osolodkin D.I., Romanov G.A.
Phytochemistry, 2018
5.
Natural and synthetic cytokinins and their applications in biotechnology, agrochemistry and medicine
Oshchepkov M.S., Kalistratova A.V., Savelieva E.M., Romanov G.A., Bystrova N.A., Kochetkov K.A.
Russian Chemical Reviews, 2020
6.
Anticancer activity of natural cytokinins: A structure–activity relationship study
Voller J., Zatloukal M., Lenobel R., Doležal K., Béreš T., Kryštof V., Spíchal L., Niemann P., Džubák P., Hajdúch M., Strnad M.
Phytochemistry, 2010
8.
Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor
Ciaglia E., Abate M., Laezza C., Pisanti S., Vitale M., Seneca V., Torelli G., Franceschelli S., Catapano G., Gazzerro P., Bifulco M.
International Journal of Cancer, 2016
9.
Recognition by natural killer cells of N6-isopentenyladenosine-treated human glioma cell lines
Ciaglia E., Laezza C., Abate M., Pisanti S., Ranieri R., D'alessandro A., Picardi P., Gazzerro P., Bifulco M.
International Journal of Cancer, 2017
10.
The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the “classical” cytokinin ribosides
Voller J., Béres T., Zatloukal M., Kaminski P.A., Niemann P., Doležal K., Džubák P., Hajdúch M., Strnad M.
Phytochemistry, 2017
14.
J. S. Kerr, G. A. Boswell, US Patent 5001141A, 1991.
16.
Spindola D.G., Hinsberger A., Antunes V.M., Michelin L.F., Bincoletto C., Oliveira C.R.
Brazilian Journal of Pharmaceutical Sciences, 2018
17.
Differential response to CoCl2-stimulated hypoxia on HIF-1α, VEGF, and MMP-2 expression in ligament cells
Wang Y., Tang Z., Xue R., Singh G.K., Liu W., Lv Y., Yang L.
Molecular and Cellular Biochemistry, 2011
18.
Glucose Withdrawal Induces Oxidative Stress followed by Apoptosis in Glioblastoma Cells but not in Normal Human Astrocytes
Jelluma N., Yang X., Stokoe D., Evan G.I., Dansen T.B., Haas-Kogan D.A.
Molecular Cancer Research, 2006
19.
Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y
Akimov M.G., Ashba A.M., Fomina-Ageeva E.V., Gretskaya N.M., Myasoedov N.F., Bezuglov V.V.
Doklady Biochemistry and Biophysics, 2019
20.
P. Lardenois, J. Frost, P. Pasau, P. George, M.C. Renones, R. Bartsch, W.-T. Li, P. Magat, R. Dupont, US Patent WO 009309, 1997.