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Hybrid systems for oral delivery of a therapeutic neuropeptide

Natalia Nikolaevna Sudareva 1, 2
Natalia Nikolaevna Sudareva
,  ,  ,  ,  , 
Sergey Gervasievich Petunov 3, 4
Sergey Gervasievich Petunov
, 
Andrey Stanislavovich Radilov 3
Andrey Stanislavovich Radilov
, 
Alexander Sergeevich Timin 2
Alexander Sergeevich Timin
, 
Evgenia Georgievna Korzhikova-Vlakh 1
Evgenia Georgievna Korzhikova-Vlakh
, 
Alexander D Vilesov 1, 2
Alexander D Vilesov
10.1016/j.mencom.2020.01.008
Published 2019-12-30
Communication , Volume 30, Issue 1, 25-27
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Sudareva N. N. et al. Hybrid systems for oral delivery of a therapeutic neuropeptide // Mendeleev Communications. 2019. Vol. 30. No. 1. pp. 25-27.
GOST all authors (up to 50) Copy
Sudareva N. N., Suvorova O. M., Tarasenko I. I., Saprykina N. N., Smirnova N. V., Petunov S. G., Radilov A. S., Timin A. S., Korzhikova-Vlakh E. G., Vilesov A. D. Hybrid systems for oral delivery of a therapeutic neuropeptide // Mendeleev Communications. 2019. Vol. 30. No. 1. pp. 25-27.
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TY - JOUR
DO - 10.1016/j.mencom.2020.01.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.008
TI - Hybrid systems for oral delivery of a therapeutic neuropeptide
T2 - Mendeleev Communications
AU - Sudareva, Natalia Nikolaevna
AU - Suvorova, Olga Mikhaylovna
AU - Tarasenko, Irina Il'inichna
AU - Saprykina, Natalia Nikolaevna
AU - Smirnova, Natalia Vladimirovna
AU - Petunov, Sergey Gervasievich
AU - Radilov, Andrey Stanislavovich
AU - Timin, Alexander Sergeevich
AU - Korzhikova-Vlakh, Evgenia Georgievna
AU - Vilesov, Alexander D
PY - 2019
DA - 2019/12/30
PB - Mendeleev Communications
SP - 25-27
IS - 1
VL - 30
ER -
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@article{2019_Sudareva,
author = {Natalia Nikolaevna Sudareva and Olga Mikhaylovna Suvorova and Irina Il'inichna Tarasenko and Natalia Nikolaevna Saprykina and Natalia Vladimirovna Smirnova and Sergey Gervasievich Petunov and Andrey Stanislavovich Radilov and Alexander Sergeevich Timin and Evgenia Georgievna Korzhikova-Vlakh and Alexander D Vilesov},
title = {Hybrid systems for oral delivery of a therapeutic neuropeptide},
journal = {Mendeleev Communications},
year = {2019},
volume = {30},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.008},
number = {1},
pages = {25--27},
doi = {10.1016/j.mencom.2020.01.008}
}
MLA
Cite this
MLA Copy
Sudareva, Natalia Nikolaevna, et al. “Hybrid systems for oral delivery of a therapeutic neuropeptide.” Mendeleev Communications, vol. 30, no. 1, Dec. 2019, pp. 25-27. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.008.

Keywords

alginate granules
encapsulation
peptide delivery systems
poly(amino acids)
silica and CaCO3 sub-microparticles
sporopollenin exine capsules

Abstract

Several hybrid systems for oral delivery of a therapeutic peptide have been prepared and investigated. Poly(l-glutamic acidco-d-phenylalanine) and silica sub-microparticles, porous CaCO3 microparticles and Lycopodium clavatum spore capsules were employed as the first level carriers included in sodium alginate granules as the second level carriers. Efficiency of the peptide encapsulation and release rate strongly depended on the nature and structure of the carriers.

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