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New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates

, 
Natalya Vital'evna Fadeeva 1
Natalya Vital'evna Fadeeva
, 
Boris Sergeevich Fedorov 1
Boris Sergeevich Fedorov
, 
Galina Ivanovna Kozub 1, 2
Galina Ivanovna Kozub
,  , 
Vladimir Alexandrovich Kurmaz 1
Vladimir Alexandrovich Kurmaz
, 
Roman Alekseevich Manzhos 1
Roman Alekseevich Manzhos
, 
Anastasya Aleksandrovna Balakina 1, 2
Anastasya Aleksandrovna Balakina
, 
Alexei Alekseevich Terentyev 1, 2
Alexei Alekseevich Terentyev
10.1016/j.mencom.2020.01.007
Published 2019-12-30
Communication , Volume 30, Issue 1, 22-24
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Kurmaz S. V. et al. New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates // Mendeleev Communications. 2019. Vol. 30. No. 1. pp. 22-24.
GOST all authors (up to 50) Copy
Kurmaz S. V., Fadeeva N. V., Fedorov B. S., Kozub G. I., Emelyanova N. S., Kurmaz V. A., Manzhos R. A., Balakina A. A., Terentyev A. A. New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates // Mendeleev Communications. 2019. Vol. 30. No. 1. pp. 22-24.
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TY - JOUR
DO - 10.1016/j.mencom.2020.01.007
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.007
TI - New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates
T2 - Mendeleev Communications
AU - Kurmaz, Svetlana Viktorovna
AU - Fadeeva, Natalya Vital'evna
AU - Fedorov, Boris Sergeevich
AU - Kozub, Galina Ivanovna
AU - Emelyanova, Nina Sergeevna
AU - Kurmaz, Vladimir Alexandrovich
AU - Manzhos, Roman Alekseevich
AU - Balakina, Anastasya Aleksandrovna
AU - Terentyev, Alexei Alekseevich
PY - 2019
DA - 2019/12/30
PB - Mendeleev Communications
SP - 22-24
IS - 1
VL - 30
ER -
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@article{2019_Kurmaz,
author = {Svetlana Viktorovna Kurmaz and Natalya Vital'evna Fadeeva and Boris Sergeevich Fedorov and Galina Ivanovna Kozub and Nina Sergeevna Emelyanova and Vladimir Alexandrovich Kurmaz and Roman Alekseevich Manzhos and Anastasya Aleksandrovna Balakina and Alexei Alekseevich Terentyev},
title = {New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates},
journal = {Mendeleev Communications},
year = {2019},
volume = {30},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.007},
number = {1},
pages = {22--24},
doi = {10.1016/j.mencom.2020.01.007}
}
MLA
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Kurmaz, Svetlana Viktorovna, et al. “New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates.” Mendeleev Communications, vol. 30, no. 1, Dec. 2019, pp. 22-24. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.007.

Keywords

(di)methacrylates
N-vinylpyrrolidone
amphiphilic copolymers
antitumor activity
cytotoxicity
hybrid materials
platinum(iv) organic complex
polymer particles

Abstract

New cis-bis[N-(2-nitroxyethyl)isonicotinamide-N]platinum(iv) tetrachloride hybrid materials were obtained via its solubilization by nanoparticles of N-vinylpyrrolidone copolymer with dimethacrylates and characterized. The materials containing 2% of PtIV complex cause a cytotoxic effect on the tumor A-172 cells; IC50 values were ca. 106μm after incubation for 48h.

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