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Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol

Natalia Alexandrovna Lozinskaya 1, 2
Natalia Alexandrovna Lozinskaya
, 
Natalia Anatol'evna Maximova 1
Natalia Anatol'evna Maximova
, 
Daniil Romanovich Bazanov 1
Daniil Romanovich Bazanov
, 
Sergey Evgen'evich Sosonyuk 1
Sergey Evgen'evich Sosonyuk
, 
Birgit Wobith 3
Birgit Wobith
, 
Nikolay Alekseevich Zefirov 1, 2
Nikolay Alekseevich Zefirov
, 
Elena Vladimirovna Kharitonashvili 1
Elena Vladimirovna Kharitonashvili
, 
Ol'ga Nikolaevna Zefirova 1, 2
Ol'ga Nikolaevna Zefirova
, 
Sergei A Kuznetsov 3
Sergei A Kuznetsov
, 
Marina Valentinovna Proskurnina 1
Marina Valentinovna Proskurnina
10.1016/j.mencom.2020.01.002
Published 2019-12-30
Communication , Volume 30, Issue 1, 7-9
2
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Lozinskaya N. A. et al. Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol // Mendeleev Communications. 2019. Vol. 30. No. 1. pp. 7-9.
GOST all authors (up to 50) Copy
Lozinskaya N. A., Maximova N. A., Bazanov D. R., Sosonyuk S. E., Wobith B., Zefirov N. A., Kharitonashvili E. V., Zefirova O. N., Kuznetsov S. A., Proskurnina M. V. Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol // Mendeleev Communications. 2019. Vol. 30. No. 1. pp. 7-9.
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TY - JOUR
DO - 10.1016/j.mencom.2020.01.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.002
TI - Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol
T2 - Mendeleev Communications
AU - Lozinskaya, Natalia Alexandrovna
AU - Maximova, Natalia Anatol'evna
AU - Bazanov, Daniil Romanovich
AU - Sosonyuk, Sergey Evgen'evich
AU - Wobith, Birgit
AU - Zefirov, Nikolay Alekseevich
AU - Kharitonashvili, Elena Vladimirovna
AU - Zefirova, Ol'ga Nikolaevna
AU - Kuznetsov, Sergei A
AU - Proskurnina, Marina Valentinovna
PY - 2019
DA - 2019/12/30
PB - Mendeleev Communications
SP - 7-9
IS - 1
VL - 30
ER -
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@article{2019_Lozinskaya,
author = {Natalia Alexandrovna Lozinskaya and Natalia Anatol'evna Maximova and Daniil Romanovich Bazanov and Sergey Evgen'evich Sosonyuk and Birgit Wobith and Nikolay Alekseevich Zefirov and Elena Vladimirovna Kharitonashvili and Ol'ga Nikolaevna Zefirova and Sergei A Kuznetsov and Marina Valentinovna Proskurnina},
title = {Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol},
journal = {Mendeleev Communications},
year = {2019},
volume = {30},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.002},
number = {1},
pages = {7--9},
doi = {10.1016/j.mencom.2020.01.002}
}
MLA
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MLA Copy
Lozinskaya, Natalia Alexandrovna, et al. “Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol.” Mendeleev Communications, vol. 30, no. 1, Dec. 2019, pp. 7-9. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2020.01.002.

Abstract

To overcome the metabolic instability of anticancer agent 2-methoxyestradiol, two its dichloroacetylated prodrugs and three new control compounds have been synthesized and evaluated in different in vitro assays with cancer cells A549 and MCF-7. Both prodrugs demonstrated an intrinsic cytotoxicity to A549 cells with no effect on the cellular microtubule network. Molecular modeling has revealed putative weak halogen bond formation of 17-O-dichloroacetylated 2-methoxyestradiol with GTP in the a-tubulin subunit.

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