Home / Publications / Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines

Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines

, 
Denis Nikolaevich Tomilin 1
Denis Nikolaevich Tomilin
, 
Olga Vital'evna Petrova 1
Olga Vital'evna Petrova
, 
Arsalan Badmaevich Budaev 1
Arsalan Badmaevich Budaev
,  , 
Boris Aleksandrovich Trofimov 1
Boris Aleksandrovich Trofimov
, 
Guoqiang Q Yang 2
Guoqiang Q Yang
, 
Rui Hu 2
Rui Hu
10.1016/j.mencom.2019.11.018
Published 2019-11-01
Communication , Volume 29, Issue 6, 658-660
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Sagitova E. F. et al. Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines // Mendeleev Communications. 2019. Vol. 29. No. 6. pp. 658-660.
GOST all authors (up to 50) Copy
Sagitova E. F., Tomilin D. N., Petrova O. V., Budaev A. B., Sobenina L. N., Trofimov B. A., Yang G. Q., Hu R. Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines // Mendeleev Communications. 2019. Vol. 29. No. 6. pp. 658-660.
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TY - JOUR
DO - 10.1016/j.mencom.2019.11.018
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.018
TI - Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines
T2 - Mendeleev Communications
AU - Sagitova, Elena Faritovna
AU - Tomilin, Denis Nikolaevich
AU - Petrova, Olga Vital'evna
AU - Budaev, Arsalan Badmaevich
AU - Sobenina, Lyubov Nikolaevna
AU - Trofimov, Boris Aleksandrovich
AU - Yang, Guoqiang Q
AU - Hu, Rui
PY - 2019
DA - 2019/11/01
PB - Mendeleev Communications
SP - 658-660
IS - 6
VL - 29
ER -
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@article{2019_Sagitova,
author = {Elena Faritovna Sagitova and Denis Nikolaevich Tomilin and Olga Vital'evna Petrova and Arsalan Badmaevich Budaev and Lyubov Nikolaevna Sobenina and Boris Aleksandrovich Trofimov and Guoqiang Q Yang and Rui Hu},
title = {Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.018},
number = {6},
pages = {658--660},
doi = {10.1016/j.mencom.2019.11.018}
}
MLA
Cite this
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Sagitova, Elena Faritovna, et al. “Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines.” Mendeleev Communications, vol. 29, no. 6, Nov. 2019, pp. 658-660. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.018.

Abstract

Pharmaceutically relevant substituted 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo [3,2-c]pyridines have been assembled in good to excellent yields via the reaction of 2,2,6,6-tetramethylpiperidin-4-one oxime with acetylene, cross-coupling of the resulting 4,4,6,6-tetramethyl-4,5,6,7 tetrahydropyrrolo[3,2-c]pyridines with aroylbromoacetylenes, and reaction of the formed 2-(aroylethynyl)-4,4,6,6-tetramethyl-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines with hydrazine.

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