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Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication

Maria Petrovna Paramonova 1
Maria Petrovna Paramonova
, 
Alexander Alexandrovich Ozerov 1
Alexander Alexandrovich Ozerov
, 
Alexander Olegovich Chizhov 2
Alexander Olegovich Chizhov
, 
Robert Snoeck 3
Robert Snoeck
, 
Graciela Andrei 3
Graciela Andrei
, 
Anastasia Lvovna Khandazhinskaya 4
Anastasia Lvovna Khandazhinskaya
, 
Mikhail Stanislavovich Novikov 1
Mikhail Stanislavovich Novikov
10.1016/j.mencom.2019.11.010
Published 2019-11-01
Communication , Volume 29, Issue 6, 638-639
7
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Paramonova M. P. et al. Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication // Mendeleev Communications. 2019. Vol. 29. No. 6. pp. 638-639.
GOST all authors (up to 50) Copy
Paramonova M. P., Ozerov A. A., Chizhov A. O., Snoeck R., Andrei G., Khandazhinskaya A. L., Novikov M. S. Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication // Mendeleev Communications. 2019. Vol. 29. No. 6. pp. 638-639.
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TY - JOUR
DO - 10.1016/j.mencom.2019.11.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.010
TI - Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication
T2 - Mendeleev Communications
AU - Paramonova, Maria Petrovna
AU - Ozerov, Alexander Alexandrovich
AU - Chizhov, Alexander Olegovich
AU - Snoeck, Robert
AU - Andrei, Graciela
AU - Khandazhinskaya, Anastasia Lvovna
AU - Novikov, Mikhail Stanislavovich
PY - 2019
DA - 2019/11/01
PB - Mendeleev Communications
SP - 638-639
IS - 6
VL - 29
ER -
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@article{2019_Paramonova,
author = {Maria Petrovna Paramonova and Alexander Alexandrovich Ozerov and Alexander Olegovich Chizhov and Robert Snoeck and Graciela Andrei and Anastasia Lvovna Khandazhinskaya and Mikhail Stanislavovich Novikov},
title = {Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.010},
number = {6},
pages = {638--639},
doi = {10.1016/j.mencom.2019.11.010}
}
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Paramonova, Maria Petrovna, et al. “Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication.” Mendeleev Communications, vol. 29, no. 6, Nov. 2019, pp. 638-639. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.010.

Abstract

A series of 1-[(bromophenoxy)alkyl]uracil–coumarin conjugates has been obtained through the preparation of starting 1-[(bromophenoxy)alkyl]uracil derivatives, followed by their treatment with 7-(ω-bromoalkoxy)-4-methyl-2H-chromen-2-ones. Two of the synthesized uracil–coumarin conjugates demonstrated a pronounced inhibitory activity against HCMV and VZV replication in vitro.

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