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Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators

Mstislav Igorevich Lavrov 1, 2
Mstislav Igorevich Lavrov
,  , 
Dmitry Sergeevich Karlov 1, 3
Dmitry Sergeevich Karlov
, 
Vladimir Lollievich Zamoyski 2
Vladimir Lollievich Zamoyski
, 
Vladimir Viktorovich Grigoriev 1, 2
Vladimir Viktorovich Grigoriev
, 
Vladimir Alexandrovich Palyulin 1, 2
Vladimir Alexandrovich Palyulin
10.1016/j.mencom.2019.11.004
Published 2019-11-01
Communication , Volume 29, Issue 6, 619-621
17
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Lavrov M. I. et al. Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators // Mendeleev Communications. 2019. Vol. 29. No. 6. pp. 619-621.
GOST all authors (up to 50) Copy
Lavrov M. I., Veremeeva P. N., Karlov D. S., Zamoyski V. L., Grigoriev V. V., Palyulin V. A. Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators // Mendeleev Communications. 2019. Vol. 29. No. 6. pp. 619-621.
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TY - JOUR
DO - 10.1016/j.mencom.2019.11.004
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.004
TI - Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators
T2 - Mendeleev Communications
AU - Lavrov, Mstislav Igorevich
AU - Veremeeva, Polina Nikolaevna
AU - Karlov, Dmitry Sergeevich
AU - Zamoyski, Vladimir Lollievich
AU - Grigoriev, Vladimir Viktorovich
AU - Palyulin, Vladimir Alexandrovich
PY - 2019
DA - 2019/11/01
PB - Mendeleev Communications
SP - 619-621
IS - 6
VL - 29
ER -
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@article{2019_Lavrov,
author = {Mstislav Igorevich Lavrov and Polina Nikolaevna Veremeeva and Dmitry Sergeevich Karlov and Vladimir Lollievich Zamoyski and Vladimir Viktorovich Grigoriev and Vladimir Alexandrovich Palyulin},
title = {Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.004},
number = {6},
pages = {619--621},
doi = {10.1016/j.mencom.2019.11.004}
}
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Cite this
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Lavrov, Mstislav Igorevich, et al. “Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators.” Mendeleev Communications, vol. 29, no. 6, Nov. 2019, pp. 619-621. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.11.004.

Abstract

Four new tricyclic derivatives of 3,7-diazabicyclo[3.3.1]-nonane (bispidine) have been synthesized. In vitro patch clamp investigation has revealed for one of them the positive modulation of the kainate-induced AMPA receptor currents in a nanomolar concentration range, and for two other compounds the corresponding negative modulation has been demonstrated.

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