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Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer

Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
, 
Nikita Andreevich Frolov 1
Nikita Andreevich Frolov
, 
Valeria Yuryevna Konyuhova 1, 2
Valeria Yuryevna Konyuhova
, 
Karl A Hansford 3
Karl A Hansford
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.1016/j.mencom.2019.09.015
Published 2019-09-04
Communication , Volume 29, Issue 5, 523-525
25
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Vereshchagin A. N. et al. Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 523-525.
GOST all authors (up to 50) Copy
Vereshchagin A. N., Frolov N. A., Konyuhova V. Y., Hansford K. A., Egorov M. P. Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 523-525.
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TY - JOUR
DO - 10.1016/j.mencom.2019.09.015
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.015
TI - Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer
T2 - Mendeleev Communications
AU - Vereshchagin, Anatoly Nikolaevich
AU - Frolov, Nikita Andreevich
AU - Konyuhova, Valeria Yuryevna
AU - Hansford, Karl A
AU - Egorov, Mikhail Petrovich
PY - 2019
DA - 2019/09/04
PB - Mendeleev Communications
SP - 523-525
IS - 5
VL - 29
ER -
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@article{2019_Vereshchagin,
author = {Anatoly Nikolaevich Vereshchagin and Nikita Andreevich Frolov and Valeria Yuryevna Konyuhova and Karl A Hansford and Mikhail Petrovich Egorov},
title = {Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.015},
number = {5},
pages = {523--525},
doi = {10.1016/j.mencom.2019.09.015}
}
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Vereshchagin, Anatoly Nikolaevich, et al. “Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer.” Mendeleev Communications, vol. 29, no. 5, Sep. 2019, pp. 523-525. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.015.

Abstract

Novel gemini (tail–head–spacer–head–tail) bis-quaternary ammonium compounds with a 4,4′-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogues bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in vitro activity against five bacterial strains and two fungi, with minimum inhibtory concentrations relatively independent of the counter ion.

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