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Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene

, 
Yuliya Anatol'evna Valiullina 2
Yuliya Anatol'evna Valiullina
, 
Chang T Chan 1
Chang T Chan
,  , 
Pavel Leonidovich Padnya 1
Pavel Leonidovich Padnya
, 
Yuri Fedorovich Zuev 2, 3
Yuri Fedorovich Zuev
, 
10.1016/j.mencom.2019.09.014
Published 2019-09-04
Communication , Volume 29, Issue 5, 520-522
8
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Mostovaya O. A. et al. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 520-522.
GOST all authors (up to 50) Copy
Mostovaya O. A., Valiullina Y. A., Chan C. T., Terent'eva O. S., Padnya P. L., Zuev Y. F., Stoikov I. I. Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 520-522.
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TY - JOUR
DO - 10.1016/j.mencom.2019.09.014
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.014
TI - Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene
T2 - Mendeleev Communications
AU - Mostovaya, Olga Aleksandrovna
AU - Valiullina, Yuliya Anatol'evna
AU - Chan, Chang T
AU - Terent'eva, Olga Sergeevna
AU - Padnya, Pavel Leonidovich
AU - Zuev, Yuri Fedorovich
AU - Stoikov, Ivan Ivanovich
PY - 2019
DA - 2019/09/04
PB - Mendeleev Communications
SP - 520-522
IS - 5
VL - 29
ER -
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@article{2019_Mostovaya,
author = {Olga Aleksandrovna Mostovaya and Yuliya Anatol'evna Valiullina and Chang T Chan and Olga Sergeevna Terent'eva and Pavel Leonidovich Padnya and Yuri Fedorovich Zuev and Ivan Ivanovich Stoikov},
title = {Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.014},
number = {5},
pages = {520--522},
doi = {10.1016/j.mencom.2019.09.014}
}
MLA
Cite this
MLA Copy
Mostovaya, Olga Aleksandrovna, et al. “Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene.” Mendeleev Communications, vol. 29, no. 5, Sep. 2019, pp. 520-522. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.014.

Abstract

A p-tert-butylthiacalix[4]arene derivative containing tryptophan moieties on the lower rim was synthesized and proposed as a chymotrypsin inhibitor. Its ability to competitively inhibit the enzyme was revealed by kinetic methods. A mechanism of the inhibitory action has been established, which consists in the binding of macrocycle tryptophan moieties to the enzyme active site, resulting in its blocking.

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