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Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling

Shiyu Wang 1, 2
Shiyu Wang
, 
Feifan Liu 1, 2
Feifan Liu
, 
Jiaobing Fang 1, 2
Jiaobing Fang
, 
Yashu Li 1, 2
Yashu Li
, 
Jun Liu 1, 2
Jun Liu
, 
Mingzhe Liu 1, 2, 3
Mingzhe Liu
10.1016/j.mencom.2019.09.008
Published 2019-09-04
Communication , Volume 29, Issue 5, 503-505
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Wang S. et al. Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 503-505.
GOST all authors (up to 50) Copy
Wang S., Liu F., Fang J., Li Y., Liu J., Liu M. Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling // Mendeleev Communications. 2019. Vol. 29. No. 5. pp. 503-505.
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TY - JOUR
DO - 10.1016/j.mencom.2019.09.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.008
TI - Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling
T2 - Mendeleev Communications
AU - Wang, Shiyu
AU - Liu, Feifan
AU - Fang, Jiaobing
AU - Li, Yashu
AU - Liu, Jun
AU - Liu, Mingzhe
PY - 2019
DA - 2019/09/04
PB - Mendeleev Communications
SP - 503-505
IS - 5
VL - 29
ER -
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@article{2019_Wang,
author = {Shiyu Wang and Feifan Liu and Jiaobing Fang and Yashu Li and Jun Liu and Mingzhe Liu},
title = {Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.008},
number = {5},
pages = {503--505},
doi = {10.1016/j.mencom.2019.09.008}
}
MLA
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Wang, Shiyu, et al. “Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling.” Mendeleev Communications, vol. 29, no. 5, Sep. 2019, pp. 503-505. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.09.008.

Abstract

A new 5′-dimethoxytrityl N6-alkynylated 2′-deoxyadenosine phosphoramidite has been designed and synthesized from 2′-deoxyadenosine. The applicability of this building block for the production of alkyne-modified oligodeoxynucleotide has been demonstrated. This allows one to introduce various labels into DNA using the click reaction.

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