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Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins

Nikolay Sergeyevich Vostrikov 1
Nikolay Sergeyevich Vostrikov
, 
Leonid Vasilevich Spirikhin 1
Leonid Vasilevich Spirikhin
, 
Alexander Nikolaevich Lobov 1
Alexander Nikolaevich Lobov
, 
Airat Maratovich Gimazetdinov 1
Airat Maratovich Gimazetdinov
, 
Zulfiya Rustamovna Zileeva 2
Zulfiya Rustamovna Zileeva
, 
Yulia Venerovna Vakhitova 2
Yulia Venerovna Vakhitova
, 
Zainutdin Ramilevich Macaev 1
Zainutdin Ramilevich Macaev
, 
Kazimir Konstantinovich Pivnitsky 3
Kazimir Konstantinovich Pivnitsky
, 
Mansur Sagar'yarovich Miftakhov 1
Mansur Sagar'yarovich Miftakhov
10.1016/j.mencom.2019.07.003
Published 2019-07-01
Communication , Volume 29, Issue 4, 372-374
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Vostrikov N. S. et al. Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins // Mendeleev Communications. 2019. Vol. 29. No. 4. pp. 372-374.
GOST all authors (up to 50) Copy
Vostrikov N. S., Spirikhin L. V., Lobov A. N., Gimazetdinov A. M., Zileeva Z. R., Vakhitova Y. V., Macaev Z. R., Pivnitsky K. K., Miftakhov M. S. Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins // Mendeleev Communications. 2019. Vol. 29. No. 4. pp. 372-374.
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TY - JOUR
DO - 10.1016/j.mencom.2019.07.003
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.07.003
TI - Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins
T2 - Mendeleev Communications
AU - Vostrikov, Nikolay Sergeyevich
AU - Spirikhin, Leonid Vasilevich
AU - Lobov, Alexander Nikolaevich
AU - Gimazetdinov, Airat Maratovich
AU - Zileeva, Zulfiya Rustamovna
AU - Vakhitova, Yulia Venerovna
AU - Macaev, Zainutdin Ramilevich
AU - Pivnitsky, Kazimir Konstantinovich
AU - Miftakhov, Mansur Sagar'yarovich
PY - 2019
DA - 2019/07/01
PB - Mendeleev Communications
SP - 372-374
IS - 4
VL - 29
ER -
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@article{2019_Vostrikov,
author = {Nikolay Sergeyevich Vostrikov and Leonid Vasilevich Spirikhin and Alexander Nikolaevich Lobov and Airat Maratovich Gimazetdinov and Zulfiya Rustamovna Zileeva and Yulia Venerovna Vakhitova and Zainutdin Ramilevich Macaev and Kazimir Konstantinovich Pivnitsky and Mansur Sagar'yarovich Miftakhov},
title = {Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.07.003},
number = {4},
pages = {372--374},
doi = {10.1016/j.mencom.2019.07.003}
}
MLA
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MLA Copy
Vostrikov, Nikolay Sergeyevich, et al. “Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins.” Mendeleev Communications, vol. 29, no. 4, Jul. 2019, pp. 372-374. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.07.003.

Abstract

Unstable methyl (5-methylidene-4-oxocyclopent-2-en-1-yl)acetate, having a ring moiety of J-type prostaglandins (PGJs) and similar cytotoxicity, reacts with EtSH and other thiols with formation of mono-and bis-adducts, which have been further converted by oxidation with mCPBA into corresponding stable mono-sulfones possessing cytotoxic effect most probably due to in vivo regeneration of the starting dienone. Thus, the derived sulfones can be used as transport forms for original dienone as a pharmacologically important moiety of Δ12-PGJ2 and similar prostaglandins.

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