Home / Publications / A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne

A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne

Sravya Gundala 1, 2
Sravya Gundala
, 
Mallikarjuna Reddy Guda 1, 3
Mallikarjuna Reddy Guda
, 
Albert Faridovich Khasanov 1, 4
Albert Faridovich Khasanov
, 
Dmitrii Sergeevich Kopchuk 1, 4
Dmitrii Sergeevich Kopchuk
, 
Alexey P Krinochkin 1, 4
Alexey P Krinochkin
, 
Sougata Santra 1
Sougata Santra
, 
Grigory Vasil'evich Zyryanov 1, 4
Grigory Vasil'evich Zyryanov
, 
Padmavathi Venkatapuram 2
Padmavathi Venkatapuram
, 
Jarem Raul Garcia 3
Jarem Raul Garcia
, 
Valery Nikolaevich Charushin 1, 4
Valery Nikolaevich Charushin
10.1016/j.mencom.2019.07.002
Published 2019-07-01
Communication , Volume 29, Issue 4, 369-371
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Gundala S. et al. A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne // Mendeleev Communications. 2019. Vol. 29. No. 4. pp. 369-371.
GOST all authors (up to 50) Copy
Gundala S., Guda M. R., Khasanov A. F., Kopchuk D. S., Krinochkin A. P., Santra S., Zyryanov G. V., Venkatapuram P., Garcia J. R., Charushin V. N. A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne // Mendeleev Communications. 2019. Vol. 29. No. 4. pp. 369-371.
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TY - JOUR
DO - 10.1016/j.mencom.2019.07.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.07.002
TI - A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne
T2 - Mendeleev Communications
AU - Gundala, Sravya
AU - Guda, Mallikarjuna Reddy
AU - Khasanov, Albert Faridovich
AU - Kopchuk, Dmitrii Sergeevich
AU - Krinochkin, Alexey P
AU - Santra, Sougata
AU - Zyryanov, Grigory Vasil'evich
AU - Venkatapuram, Padmavathi
AU - Garcia, Jarem Raul
AU - Charushin, Valery Nikolaevich
PY - 2019
DA - 2019/07/01
PB - Mendeleev Communications
SP - 369-371
IS - 4
VL - 29
ER -
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@article{2019_Gundala,
author = {Sravya Gundala and Mallikarjuna Reddy Guda and Albert Faridovich Khasanov and Dmitrii Sergeevich Kopchuk and Alexey P Krinochkin and Sougata Santra and Grigory Vasil'evich Zyryanov and Padmavathi Venkatapuram and Jarem Raul Garcia and Valery Nikolaevich Charushin},
title = {A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.07.002},
number = {4},
pages = {369--371},
doi = {10.1016/j.mencom.2019.07.002}
}
MLA
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Gundala, Sravya, et al. “A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne.” Mendeleev Communications, vol. 29, no. 4, Jul. 2019, pp. 369-371. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.07.002.

Abstract

12-(1H-1,2,3-Triazol-1-yl)indolo[2,1-a]isoquinolines are prepared in 51–56% yields using a PASE (pot, atom, step, economic)-based approach, namely, by the reaction between available 5-R-6-Ar-3-(isoquinolin-1-yl)-1,2,4-triazines and in situ generated benzyne. A mechanism comprising domino-transformation was suggested, and the structure of one key product was confirmed by a single crystal X-ray diffraction analysis.

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10.1016/j.mencom.2019.07.002_bib0210
Sheldrick
2008