Abstract
The double anodic C–H functionalization of N-methyl-1H-pyrrole and N,N-dimethylaniline using both thiocyanate and 4-nitro-1H-pyrazolate ions as nucleophiles has been accomplished for the first time. The mild reaction conditions and considerable pharmacological activity of the target products make such C–S and C–N coupling strategy to be highly attractive for further applications.
References
1.
Davies H.M., Morton D.
Angewandte Chemie - International Edition,
2014
2.
Chupakhin O.N., Charushin V.N.
Pure and Applied Chemistry,
2017
3.
10.1016/j.mencom.2019.05.032_bib0015
Organic Electrochemistry,
1973
4.
Petrosyan V.A.
Mendeleev Communications,
2011
5.
Shchepochkin A.V., Chupakhin O.N., Charushin V.N., Petrosyan V.A.
Russian Chemical Reviews,
2013
6.
Kärkäs M.D.
Chemical Society Reviews,
2018
7.
Yang Q., Fang P., Mei T.
Chinese Journal of Chemistry,
2018
8.
Kokorekin V.A., Solomatin Y.A., Gening M.L., Petrosyan V.A.
Mendeleev Communications,
2017
9.
Kokorekin V.A., Sigacheva V.L., Petrosyan V.A.
Tetrahedron Letters,
2014
10.
Kokorekin V.A., Yaubasarova R.R., Neverov S.V., Petrosyan V.A.
Mendeleev Communications,
2016
11.
Sigacheva V.L., Kokorekin V.A., Strelenko Y.A., Neverov S.V., Petrosyan V.A.
Mendeleev Communications,
2012
12.
Kokorekin V.A., Terent’ev A.O., Ramenskaya G.V., Grammatikova N.É., Rodionova G.M., Ilovaiskii A.I.
Pharmaceutical Chemistry Journal,
2013
13.
V.A. Kokorekin, PhD Thesis, 2013.(in Russian).
14.
Ananikov V.P., Eremin D.B., Yakukhnov S.A., Dilman A.D., Levin V.V., Egorov M.P., Karlov S.S., Kustov L.M., Tarasov A.L., Greish A.A., Shesterkina A.A., Sakharov A.M., Nysenko Z.N., Sheremetev A.B., Stakheev A.Y., et. al.
Mendeleev Communications,
2017
15.
10.1016/j.mencom.2019.05.032_bib0075
Yoshida
Electrooxidation in Organic Chemistry. The Role of Cation Radicals as Synthetic Intermediates,
1984
16.
Lass-Flörl C., Mayr A., Perkhofer S., Hinterberger G., Hausdorfer J., Speth C., Fille M.
Antimicrobial Agents and Chemotherapy,
2008
17.
10.1016/j.mencom.2019.05.032_bib0085
M07. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically,
2017
18.
10.1016/j.mencom.2019.05.032_bib0090
M27. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts,
2017