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Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies

Galina Valentinovna Pazynina 1
Galina Valentinovna Pazynina
, 
Svetlana Vladimirovna Tsygankova 1
Svetlana Vladimirovna Tsygankova
, 
Ivan Mikhailovich Ryzhov 1
Ivan Mikhailovich Ryzhov
, 
Nadezhda Vladimirovna Shilova 1
Nadezhda Vladimirovna Shilova
, 
Svetlana Mikhailovna Polyakova 1
Svetlana Mikhailovna Polyakova
, 
Alexander Sergeyevich Paramonov 1
Alexander Sergeyevich Paramonov
, 
Andrey Alfredovich Formanovsky 1
Andrey Alfredovich Formanovsky
, 
10.1016/j.mencom.2019.05.004
Published 2019-04-26
Communication , Volume 29, Issue 3, 254-255
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Pazynina G. V. et al. Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies // Mendeleev Communications. 2019. Vol. 29. No. 3. pp. 254-255.
GOST all authors (up to 50) Copy
Pazynina G. V., Tsygankova S. V., Ryzhov I. M., Shilova N. V., Polyakova S. M., Paramonov A. S., Formanovsky A. A., Bovin N. V. Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies // Mendeleev Communications. 2019. Vol. 29. No. 3. pp. 254-255.
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TY - JOUR
DO - 10.1016/j.mencom.2019.05.004
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.004
TI - Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies
T2 - Mendeleev Communications
AU - Pazynina, Galina Valentinovna
AU - Tsygankova, Svetlana Vladimirovna
AU - Ryzhov, Ivan Mikhailovich
AU - Shilova, Nadezhda Vladimirovna
AU - Polyakova, Svetlana Mikhailovna
AU - Paramonov, Alexander Sergeyevich
AU - Formanovsky, Andrey Alfredovich
AU - Bovin, Nicolai Vladimirovich
PY - 2019
DA - 2019/04/26
PB - Mendeleev Communications
SP - 254-255
IS - 3
VL - 29
ER -
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@article{2019_Pazynina,
author = {Galina Valentinovna Pazynina and Svetlana Vladimirovna Tsygankova and Ivan Mikhailovich Ryzhov and Nadezhda Vladimirovna Shilova and Svetlana Mikhailovna Polyakova and Alexander Sergeyevich Paramonov and Andrey Alfredovich Formanovsky and Nicolai Vladimirovich Bovin},
title = {Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.004},
number = {3},
pages = {254--255},
doi = {10.1016/j.mencom.2019.05.004}
}
MLA
Cite this
MLA Copy
Pazynina, Galina Valentinovna, et al. “Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies.” Mendeleev Communications, vol. 29, no. 3, Apr. 2019, pp. 254-255. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.004.

Abstract

We have synthesized GalNGcα1-3GalNAcα disaccharide, a glycoloyl analogue of GalNAcα1-3GalNAcα known as the core 5 motif of mucin-type glycoproteins, and investigated how this structural variation affects the interaction with human natural antibodies. In contrast to the case of the Neu5NGc/Neu5NAc pair, the additional glycoloyl OH group in GalNGcα1-3GalNAcα markedly reduced the antigenicity of the GalNGcα moiety.

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