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Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives

Danila Vladimirovich Belyaev 1
Danila Vladimirovich Belyaev
, 
Dmitrii Leonidovich Chizhov 1
Dmitrii Leonidovich Chizhov
, 
Mikhail Isaakovich Kodess 1, 2
Mikhail Isaakovich Kodess
, 
Marina Aleksandrovna Ezhikova 1
Marina Aleksandrovna Ezhikova
, 
Gennady Leonidovich Rusinov 1, 2
Gennady Leonidovich Rusinov
, 
Valery Nikolaevich Charushin 1, 2
Valery Nikolaevich Charushin
10.1016/j.mencom.2019.05.002
Published 2019-04-26
Communication , Volume 29, Issue 3, 249-251
8
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Belyaev D. V. et al. Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives // Mendeleev Communications. 2019. Vol. 29. No. 3. pp. 249-251.
GOST all authors (up to 50) Copy
Belyaev D. V., Chizhov D. L., Kodess M. I., Ezhikova M. A., Rusinov G. L., Charushin V. N. Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives // Mendeleev Communications. 2019. Vol. 29. No. 3. pp. 249-251.
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TY - JOUR
DO - 10.1016/j.mencom.2019.05.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.002
TI - Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives
T2 - Mendeleev Communications
AU - Belyaev, Danila Vladimirovich
AU - Chizhov, Dmitrii Leonidovich
AU - Kodess, Mikhail Isaakovich
AU - Ezhikova, Marina Aleksandrovna
AU - Rusinov, Gennady Leonidovich
AU - Charushin, Valery Nikolaevich
PY - 2019
DA - 2019/04/26
PB - Mendeleev Communications
SP - 249-251
IS - 3
VL - 29
ER -
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@article{2019_Belyaev,
author = {Danila Vladimirovich Belyaev and Dmitrii Leonidovich Chizhov and Mikhail Isaakovich Kodess and Marina Aleksandrovna Ezhikova and Gennady Leonidovich Rusinov and Valery Nikolaevich Charushin},
title = {Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.002},
number = {3},
pages = {249--251},
doi = {10.1016/j.mencom.2019.05.002}
}
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Cite this
MLA Copy
Belyaev, Danila Vladimirovich, et al. “Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives.” Mendeleev Communications, vol. 29, no. 3, Apr. 2019, pp. 249-251. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.05.002.

Abstract

A simple and efficient synthesis of 2-RF-pyrimido[1,2-a]benzimidazole-4-carbaldehyde derivatives comprises the reaction between 3-(polyfluoroacetyl)pyruvaldehyde dimethyl acetals and 2-aminobenzimidazole. The effects of fluorinated substituents in 3-(polyfluoroacetyl)pyruvaldehyde dimethyl acetals and the reaction conditions on regiochemical outcome of this reaction have been estimated.

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