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Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors

Gennady Borisovich Lapa 1
Gennady Borisovich Lapa
, 
Alla A Lapa 2
Alla A Lapa
10.1016/j.mencom.2019.03.030
Published 2019-03-01
Communication , Volume 29, Issue 2, 203-205
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Lapa G. B., Lapa A. A. Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors // Mendeleev Communications. 2019. Vol. 29. No. 2. pp. 203-205.
GOST all authors (up to 50) Copy
Lapa G. B., Lapa A. A. Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors // Mendeleev Communications. 2019. Vol. 29. No. 2. pp. 203-205.
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TY - JOUR
DO - 10.1016/j.mencom.2019.03.030
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.03.030
TI - Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors
T2 - Mendeleev Communications
AU - Lapa, Gennady Borisovich
AU - Lapa, Alla A
PY - 2019
DA - 2019/03/01
PB - Mendeleev Communications
SP - 203-205
IS - 2
VL - 29
ER -
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@article{2019_Lapa,
author = {Gennady Borisovich Lapa and Alla A Lapa},
title = {Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.03.030},
number = {2},
pages = {203--205},
doi = {10.1016/j.mencom.2019.03.030}
}
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Lapa, Gennady Borisovich, and Alla A Lapa. “Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors.” Mendeleev Communications, vol. 29, no. 2, Mar. 2019, pp. 203-205. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.03.030.

Abstract

The library of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors was designed and synthesized. H-Bond donors in piperidine ring were found to be important for reduced locomotor activity in mice. 4-[Bis(4-fluorophenyl)methoxy]piperidine has IC50 17.0±1.0nm for dopamine transporter and locomotor activity, which is lower than that for cocaine.

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