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A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores

Dmitry Vadimovich Tsyganov 1
Dmitry Vadimovich Tsyganov
, 
Marina Nikolaevna Semenova 2
Marina Nikolaevna Semenova
, 
Leonid Dmitrievich Konyushkin 1
Leonid Dmitrievich Konyushkin
, 
Vladimir Igorevich Ushkarov 1
Vladimir Igorevich Ushkarov
, 
Mikhail Mikhailovich Raihstat 1
Mikhail Mikhailovich Raihstat
, 
Victor Vladimirovich Semenov 1
Victor Vladimirovich Semenov
10.1016/j.mencom.2019.03.015
Published 2019-03-01
Communication , Volume 29, Issue 2, 163-165
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Tsyganov D. V. et al. A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores // Mendeleev Communications. 2019. Vol. 29. No. 2. pp. 163-165.
GOST all authors (up to 50) Copy
Tsyganov D. V., Semenova M. N., Konyushkin L. D., Ushkarov V. I., Raihstat M. M., Semenov V. V. A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores // Mendeleev Communications. 2019. Vol. 29. No. 2. pp. 163-165.
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TY - JOUR
DO - 10.1016/j.mencom.2019.03.015
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.03.015
TI - A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores
T2 - Mendeleev Communications
AU - Tsyganov, Dmitry Vadimovich
AU - Semenova, Marina Nikolaevna
AU - Konyushkin, Leonid Dmitrievich
AU - Ushkarov, Vladimir Igorevich
AU - Raihstat, Mikhail Mikhailovich
AU - Semenov, Victor Vladimirovich
PY - 2019
DA - 2019/03/01
PB - Mendeleev Communications
SP - 163-165
IS - 2
VL - 29
ER -
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@article{2019_Tsyganov,
author = {Dmitry Vadimovich Tsyganov and Marina Nikolaevna Semenova and Leonid Dmitrievich Konyushkin and Vladimir Igorevich Ushkarov and Mikhail Mikhailovich Raihstat and Victor Vladimirovich Semenov},
title = {A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores},
journal = {Mendeleev Communications},
year = {2019},
volume = {29},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.03.015},
number = {2},
pages = {163--165},
doi = {10.1016/j.mencom.2019.03.015}
}
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Cite this
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Tsyganov, Dmitry Vadimovich, et al. “A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores.” Mendeleev Communications, vol. 29, no. 2, Mar. 2019, pp. 163-165. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.03.015.

Abstract

A series of combretastatin analogues, diarylpyrazoles and diarylisoxazoles, have been synthesized and evaluated for their antimitotic tubulin-binding activity using the phenotypic sea urchin (Paracentrotus lividus) embryo assay. One pyrazole analogue and four isoxazole analogues have been identified as potent antimitotic agents comparable with combretastatins A-2 and A-4, with the lowest observable effective concentration of 1–10nmoldm−3 for cleavage alteration of the test embryos.

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