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Phosphorylated flavonoids as selective carboxylesterase inhibitors

Victoria Vadimovna Abzianidze 1
Victoria Vadimovna Abzianidze
, 
Daria Stanislavovna Prokofieva 2
Daria Stanislavovna Prokofieva
, 
Petr Petrovich Beltyukov 1
Petr Petrovich Beltyukov
, 
Victor Anatol'evich Kuznetsov 1
Victor Anatol'evich Kuznetsov
, 
Alexander Sergeevich Bogachenkov 3
Alexander Sergeevich Bogachenkov
, 
Konstantin Sergeevich Rodygin 3
Konstantin Sergeevich Rodygin
1 Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
2 Institute of Experimental Pharmacology, Leningrad Region, Russian Federation
10.1016/j.mencom.2019.01.020
Published 2018-12-28
Communication , Volume 29, Issue 1, 61-63
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Abzianidze V. V. et al. Phosphorylated flavonoids as selective carboxylesterase inhibitors // Mendeleev Communications. 2018. Vol. 29. No. 1. pp. 61-63.
GOST all authors (up to 50) Copy
Abzianidze V. V., Prokofieva D. S., Beltyukov P. P., Kuznetsov V. A., Bogachenkov A. S., Rodygin K. S. Phosphorylated flavonoids as selective carboxylesterase inhibitors // Mendeleev Communications. 2018. Vol. 29. No. 1. pp. 61-63.
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TY - JOUR
DO - 10.1016/j.mencom.2019.01.020
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.020
TI - Phosphorylated flavonoids as selective carboxylesterase inhibitors
T2 - Mendeleev Communications
AU - Abzianidze, Victoria Vadimovna
AU - Prokofieva, Daria Stanislavovna
AU - Beltyukov, Petr Petrovich
AU - Kuznetsov, Victor Anatol'evich
AU - Bogachenkov, Alexander Sergeevich
AU - Rodygin, Konstantin Sergeevich
PY - 2018
DA - 2018/12/28
PB - Mendeleev Communications
SP - 61-63
IS - 1
VL - 29
ER -
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@article{2018_Abzianidze,
author = {Victoria Vadimovna Abzianidze and Daria Stanislavovna Prokofieva and Petr Petrovich Beltyukov and Victor Anatol'evich Kuznetsov and Alexander Sergeevich Bogachenkov and Konstantin Sergeevich Rodygin},
title = {Phosphorylated flavonoids as selective carboxylesterase inhibitors},
journal = {Mendeleev Communications},
year = {2018},
volume = {29},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.020},
number = {1},
pages = {61--63},
doi = {10.1016/j.mencom.2019.01.020}
}
MLA
Cite this
MLA Copy
Abzianidze, Victoria Vadimovna, et al. “Phosphorylated flavonoids as selective carboxylesterase inhibitors.” Mendeleev Communications, vol. 29, no. 1, Dec. 2018, pp. 61-63. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.020.

Abstract

A series of phosphorylated flavonoids has been synthesized and evaluated in vitro for inhibitory activity against carboxylesterase, acetylcholinesterase and butyrylcholinesterase as well as for their cytotoxicity towards human adenocarcinoma A549 and human glioblastoma U251 cell lines. Diethylphosphoryl derivatives of chrysin and 7-hydroxyflavone were found to be the most effective with bimolecular rate constants for carboxylesterase inhibition ki=2.0×106 and 5.7×106dm3mol−1min−1, respectively.

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