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Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications

Zaret Gezimahmaevna Denieva 1
Zaret Gezimahmaevna Denieva
, 
Ul'yana Alexandrovna Budanova 1
Ul'yana Alexandrovna Budanova
, 
Yurii Lvovich Sebyakin 1
Yurii Lvovich Sebyakin
10.1016/j.mencom.2019.01.009
Published 2018-12-28
Communication , Volume 29, Issue 1, 32-34
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Denieva Z. G., Budanova U. A., Sebyakin Y. L. Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications // Mendeleev Communications. 2018. Vol. 29. No. 1. pp. 32-34.
GOST all authors (up to 50) Copy
Denieva Z. G., Budanova U. A., Sebyakin Y. L. Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications // Mendeleev Communications. 2018. Vol. 29. No. 1. pp. 32-34.
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TY - JOUR
DO - 10.1016/j.mencom.2019.01.009
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.009
TI - Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications
T2 - Mendeleev Communications
AU - Denieva, Zaret Gezimahmaevna
AU - Budanova, Ul'yana Alexandrovna
AU - Sebyakin, Yurii Lvovich
PY - 2018
DA - 2018/12/28
PB - Mendeleev Communications
SP - 32-34
IS - 1
VL - 29
ER -
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@article{2018_Denieva,
author = {Zaret Gezimahmaevna Denieva and Ul'yana Alexandrovna Budanova and Yurii Lvovich Sebyakin},
title = {Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications},
journal = {Mendeleev Communications},
year = {2018},
volume = {29},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.009},
number = {1},
pages = {32--34},
doi = {10.1016/j.mencom.2019.01.009}
}
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Denieva, Zaret Gezimahmaevna, et al. “Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications.” Mendeleev Communications, vol. 29, no. 1, Dec. 2018, pp. 32-34. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.009.

Abstract

The design and synthesis of lipidic organoalkoxysilanes with different higher fatty acids as hydrophobic acyl chains for the construction of bilayer vesicles called ‘cerasomes’ were accomplished and their properties, including hydrodynamic diameter, zeta potential and encapsulation efficiency of water-soluble doxorubicin, were determined. Experiments have shown that an asymmetric hydrophobic block makes it possible to obtain cerasomes with acceptable size and stability. At the same time, the drug loading is quite high.

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