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Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine

Vera Vasil'evna Musiyak 1
Vera Vasil'evna Musiyak
, 
Dmitry Andreevich Gruzdev 1, 2
Dmitry Andreevich Gruzdev
, 
Marionella Anatol'evna Kravchenko 3
Marionella Anatol'evna Kravchenko
, 
Diana Vladimirovna Vakhrusheva 3
Diana Vladimirovna Vakhrusheva
, 
Galina L'vovna Levit 1, 2
Galina L'vovna Levit
, 
Victor Pavlovich Krasnov 1, 2
Victor Pavlovich Krasnov
, 
Valery Nikolaevich Charushin 1, 2
Valery Nikolaevich Charushin
10.1016/j.mencom.2019.01.002
Published 2018-12-28
Communication , Volume 29, Issue 1, 11-13
12
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Musiyak V. V. et al. Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine // Mendeleev Communications. 2018. Vol. 29. No. 1. pp. 11-13.
GOST all authors (up to 50) Copy
Musiyak V. V., Gruzdev D. A., Kravchenko M. A., Vakhrusheva D. V., Levit G. L., Krasnov V. P., Charushin V. N. Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine // Mendeleev Communications. 2018. Vol. 29. No. 1. pp. 11-13.
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TY - JOUR
DO - 10.1016/j.mencom.2019.01.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.002
TI - Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine
T2 - Mendeleev Communications
AU - Musiyak, Vera Vasil'evna
AU - Gruzdev, Dmitry Andreevich
AU - Kravchenko, Marionella Anatol'evna
AU - Vakhrusheva, Diana Vladimirovna
AU - Levit, Galina L'vovna
AU - Krasnov, Victor Pavlovich
AU - Charushin, Valery Nikolaevich
PY - 2018
DA - 2018/12/28
PB - Mendeleev Communications
SP - 11-13
IS - 1
VL - 29
ER -
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@article{2018_Musiyak,
author = {Vera Vasil'evna Musiyak and Dmitry Andreevich Gruzdev and Marionella Anatol'evna Kravchenko and Diana Vladimirovna Vakhrusheva and Galina L'vovna Levit and Victor Pavlovich Krasnov and Valery Nikolaevich Charushin},
title = {Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine},
journal = {Mendeleev Communications},
year = {2018},
volume = {29},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.002},
number = {1},
pages = {11--13},
doi = {10.1016/j.mencom.2019.01.002}
}
MLA
Cite this
MLA Copy
Musiyak, Vera Vasil'evna, et al. “Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine.” Mendeleev Communications, vol. 29, no. 1, Dec. 2018, pp. 11-13. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2019.01.002.

Abstract

Novel purin-6-yl, 2-aminopurin-6-yl and N-(purin-6-yl)glycyl derivatives of (S)-lysine and (S)-ornithine with free α-functional groups, as well as compounds containing N9-(2-hydroxy-ethoxy)methyl substituent in the purine core have been synthesized and tested for their inhibitory effect against Mycobacterium tuberculosis strains. Among the synthesized conjugates, one compound exhibiting a significant level of antimycobacterial activity has been found.

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