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Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans

Alexander Sergeyevich Kulikov 1
Alexander Sergeyevich Kulikov
, 
Margarita Alekseevna Epishina 1
Margarita Alekseevna Epishina
, 
Artem I Churakov 1, 2
Artem I Churakov
, 
Lada Vladimirovna Anikina 3
Lada Vladimirovna Anikina
,  , 
Nina Nikolaevna Makhova 1
Nina Nikolaevna Makhova
10.1016/j.mencom.2018.11.020
Published 2018-11-01
Communication , Volume 28, Issue 6, 623-625
16
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Kulikov A. S. et al. Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans // Mendeleev Communications. 2018. Vol. 28. No. 6. pp. 623-625.
GOST all authors (up to 50) Copy
Kulikov A. S., Epishina M. A., Churakov A. I., Anikina L. V., Fershtat L. L., Makhova N. N. Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans // Mendeleev Communications. 2018. Vol. 28. No. 6. pp. 623-625.
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TY - JOUR
DO - 10.1016/j.mencom.2018.11.020
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.11.020
TI - Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans
T2 - Mendeleev Communications
AU - Kulikov, Alexander Sergeyevich
AU - Epishina, Margarita Alekseevna
AU - Churakov, Artem I
AU - Anikina, Lada Vladimirovna
AU - Fershtat, Leonid Leonidovich
AU - Makhova, Nina Nikolaevna
PY - 2018
DA - 2018/11/01
PB - Mendeleev Communications
SP - 623-625
IS - 6
VL - 28
ER -
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@article{2018_Kulikov,
author = {Alexander Sergeyevich Kulikov and Margarita Alekseevna Epishina and Artem I Churakov and Lada Vladimirovna Anikina and Leonid Leonidovich Fershtat and Nina Nikolaevna Makhova},
title = {Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.11.020},
number = {6},
pages = {623--625},
doi = {10.1016/j.mencom.2018.11.020}
}
MLA
Cite this
MLA Copy
Kulikov, Alexander Sergeyevich, et al. “Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans.” Mendeleev Communications, vol. 28, no. 6, Nov. 2018, pp. 623-625. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.11.020.

Abstract

The effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human cancer cell lines (A549, HCT116) was tested and several structures revealed moderate cytotoxic activity.

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