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New hybrid furoxan structures with antiaggregant activity

Alexander Aleksandrovich Larin 1
Alexander Aleksandrovich Larin
,  , 
Nadezhda Evgenievna Ustyuzhanina 1
Nadezhda Evgenievna Ustyuzhanina
, 
Marina Leonidovna Gening 1
Marina Leonidovna Gening
, 
Nikolay Eduardovich Nifantiev 1
Nikolay Eduardovich Nifantiev
, 
Nina Nikolaevna Makhova 1
Nina Nikolaevna Makhova
10.1016/j.mencom.2018.11.010
Published 2018-11-01
Communication , Volume 28, Issue 6, 595-597
21
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Larin A. A. et al. New hybrid furoxan structures with antiaggregant activity // Mendeleev Communications. 2018. Vol. 28. No. 6. pp. 595-597.
GOST all authors (up to 50) Copy
Larin A. A., Fershtat L. L., Ustyuzhanina N. E., Gening M. L., Nifantiev N. E., Makhova N. N. New hybrid furoxan structures with antiaggregant activity // Mendeleev Communications. 2018. Vol. 28. No. 6. pp. 595-597.
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TY - JOUR
DO - 10.1016/j.mencom.2018.11.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.11.010
TI - New hybrid furoxan structures with antiaggregant activity
T2 - Mendeleev Communications
AU - Larin, Alexander Aleksandrovich
AU - Fershtat, Leonid Leonidovich
AU - Ustyuzhanina, Nadezhda Evgenievna
AU - Gening, Marina Leonidovna
AU - Nifantiev, Nikolay Eduardovich
AU - Makhova, Nina Nikolaevna
PY - 2018
DA - 2018/11/01
PB - Mendeleev Communications
SP - 595-597
IS - 6
VL - 28
ER -
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@article{2018_Larin,
author = {Alexander Aleksandrovich Larin and Leonid Leonidovich Fershtat and Nadezhda Evgenievna Ustyuzhanina and Marina Leonidovna Gening and Nikolay Eduardovich Nifantiev and Nina Nikolaevna Makhova},
title = {New hybrid furoxan structures with antiaggregant activity},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.11.010},
number = {6},
pages = {595--597},
doi = {10.1016/j.mencom.2018.11.010}
}
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Larin, Alexander Aleksandrovich, et al. “New hybrid furoxan structures with antiaggregant activity.” Mendeleev Communications, vol. 28, no. 6, Nov. 2018, pp. 595-597. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.11.010.

Abstract

A series of functionalized furoxans was synthesized, and their effect on the platelet aggregation was estimated using a set of inducers. New hybrid structures comprising the furoxan ring and glycolic or acetylsalicylic acid motifs effectively inhibit aggregate formation induced by adenosine diphosphate and adrenaline. Studies of their NO-donor ability showed that their antiplatelet effects were mainly independent of the NO action.

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