Home / Publications / Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines

Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines

Yuriy Anatol'evich Kvashnin 1
Yuriy Anatol'evich Kvashnin
, 
Gennady Leonidovich Rusinov 1, 2
Gennady Leonidovich Rusinov
, 
Valery Nikolaevich Charushin 1, 2
Valery Nikolaevich Charushin
10.1016/j.mencom.2018.09.002
Published 2018-09-07
Communication , Volume 28, Issue 5, 461-463
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Kvashnin Y. A., Rusinov G. L., Charushin V. N. Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines // Mendeleev Communications. 2018. Vol. 28. No. 5. pp. 461-463.
GOST all authors (up to 50) Copy
Kvashnin Y. A., Rusinov G. L., Charushin V. N. Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines // Mendeleev Communications. 2018. Vol. 28. No. 5. pp. 461-463.
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TY - JOUR
DO - 10.1016/j.mencom.2018.09.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.09.002
TI - Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines
T2 - Mendeleev Communications
AU - Kvashnin, Yuriy Anatol'evich
AU - Rusinov, Gennady Leonidovich
AU - Charushin, Valery Nikolaevich
PY - 2018
DA - 2018/09/07
PB - Mendeleev Communications
SP - 461-463
IS - 5
VL - 28
ER -
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@article{2018_Kvashnin,
author = {Yuriy Anatol'evich Kvashnin and Gennady Leonidovich Rusinov and Valery Nikolaevich Charushin},
title = {Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.09.002},
number = {5},
pages = {461--463},
doi = {10.1016/j.mencom.2018.09.002}
}
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Kvashnin, Yuriy Anatol'evich, et al. “Metal-free protocol for the synthesis of novel 6-(het)aryl-5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines.” Mendeleev Communications, vol. 28, no. 5, Sep. 2018, pp. 461-463. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.09.002.

Abstract

New 5-aryl-5H-imidazo[4,5-b][1,2,5]oxadiazolo[3,4-e]pyrazines with the 6-positioned electron-rich (het)aryl substituents have been obtained from 5,6-diamino[1,2,5]oxadiazolo[3,4-b]pyrazines through the effective two-step strategy: the starting diamino compounds were treated with triethyl orthoformate, followed by the reaction with a π-excessive arene in thepresence of trifluoroacetic acid. The structures of target products were for the first time confirmed by X-ray diffraction analysis.

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