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Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones

Alexander Vladimirovich Astakhov 1
Alexander Vladimirovich Astakhov
, 
Kirill Yu Suponitsky 2
Kirill Yu Suponitsky
, 
Viktor Mikhailovich Chernyshev 1
Viktor Mikhailovich Chernyshev
10.1016/j.mencom.2018.07.034
Published 2018-06-29
Communication , Volume 28, Issue 4, 439-441
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Astakhov A. V., Suponitsky K. Yu., Chernyshev V. M. Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 439-441.
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Astakhov A. V., Suponitsky K. Yu., Chernyshev V. M. Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 439-441.
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TY - JOUR
DO - 10.1016/j.mencom.2018.07.034
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.034
TI - Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones
T2 - Mendeleev Communications
AU - Astakhov, Alexander Vladimirovich
AU - Suponitsky, Kirill Yu
AU - Chernyshev, Viktor Mikhailovich
PY - 2018
DA - 2018/06/29
PB - Mendeleev Communications
SP - 439-441
IS - 4
VL - 28
ER -
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@article{2018_Astakhov,
author = {Alexander Vladimirovich Astakhov and Kirill Yu Suponitsky and Viktor Mikhailovich Chernyshev},
title = {Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.034},
number = {4},
pages = {439--441},
doi = {10.1016/j.mencom.2018.07.034}
}
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Astakhov, Alexander Vladimirovich, et al. “Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones.” Mendeleev Communications, vol. 28, no. 4, Jun. 2018, pp. 439-441. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.034.

Abstract

An efficient synthesis of 2-amino-1-R-[1,2,4]triazolo[1,5-a]-pyrimidinium or 3-amino-2-R-[1,2,4]triazolo[4,3-a]pyrimidi- nium chloride derivatives by heterocyclization of 3,5-diamino-1-R-1,2,4-triazoles (R=Alk or Ar) with pentane-2,4-diones was developed. The process is promoted by chlorotrimethyl- silane which plays the dual role of carbonyl-activating agent and water scavenger.

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