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The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold

, 
Elena Borisovna Averina 1, 2
Elena Borisovna Averina
, 
Anna Andreevna Nazarova 1
Anna Andreevna Nazarova
,  , 
Dmitry Sergeevich Karlov 1, 2
Dmitry Sergeevich Karlov
, 
Vladimir Lollievich Zamoyski 2
Vladimir Lollievich Zamoyski
, 
Vladimir Viktorovich Grigoriev 1, 2
Vladimir Viktorovich Grigoriev
, 
Tamara Stepanovna Kuznetsova 1
Tamara Stepanovna Kuznetsova
, 
Vladimir Alexandrovich Palyulin 1, 2
Vladimir Alexandrovich Palyulin
10.1016/j.mencom.2018.07.028
Published 2018-06-29
Communication , Volume 28, Issue 4, 423-425
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Sedenkova K. N. et al. The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 423-425.
GOST all authors (up to 50) Copy
Sedenkova K. N., Averina E. B., Nazarova A. A., Grishin Y. K., Karlov D. S., Zamoyski V. L., Grigoriev V. V., Kuznetsova T. S., Palyulin V. A. The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 423-425.
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TY - JOUR
DO - 10.1016/j.mencom.2018.07.028
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.028
TI - The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold
T2 - Mendeleev Communications
AU - Sedenkova, Kseniya N
AU - Averina, Elena Borisovna
AU - Nazarova, Anna Andreevna
AU - Grishin, Yuri Konstantinovich
AU - Karlov, Dmitry Sergeevich
AU - Zamoyski, Vladimir Lollievich
AU - Grigoriev, Vladimir Viktorovich
AU - Kuznetsova, Tamara Stepanovna
AU - Palyulin, Vladimir Alexandrovich
PY - 2018
DA - 2018/06/29
PB - Mendeleev Communications
SP - 423-425
IS - 4
VL - 28
ER -
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@article{2018_Sedenkova,
author = {Kseniya N Sedenkova and Elena Borisovna Averina and Anna Andreevna Nazarova and Yuri Konstantinovich Grishin and Dmitry Sergeevich Karlov and Vladimir Lollievich Zamoyski and Vladimir Viktorovich Grigoriev and Tamara Stepanovna Kuznetsova and Vladimir Alexandrovich Palyulin},
title = {The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.028},
number = {4},
pages = {423--425},
doi = {10.1016/j.mencom.2018.07.028}
}
MLA
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MLA Copy
Sedenkova, Kseniya N., et al. “The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold.” Mendeleev Communications, vol. 28, no. 4, Jun. 2018, pp. 423-425. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.028.

Abstract

A convenient approach to novel symmetric bispyrimidine diamines comprises SNAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the kainateinduced currents in Purkinje neurons and showed negative modulating effect.

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