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New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents

Egor Vladimirovich Verbitskiy 1, 2
Egor Vladimirovich Verbitskiy
, 
Svetlana Anatol'evna Baskakova 1
Svetlana Anatol'evna Baskakova
, 
Natal’ya Avenirovna Gerasimova 3
Natal’ya Avenirovna Gerasimova
, 
Natal’ya Petrovna Evstigneeva 3
Natal’ya Petrovna Evstigneeva
, 
Natal’ya Vladimirovna Zil'berberg 3
Natal’ya Vladimirovna Zil'berberg
, 
Nikolay Vasil'evich Kungurov 3
Nikolay Vasil'evich Kungurov
, 
Marionella Anatol'evna Kravchenko 4
Marionella Anatol'evna Kravchenko
, 
Gennady Leonidovich Rusinov 1, 2
Gennady Leonidovich Rusinov
, 
Oleg Nikolaevich Chupakhin 1, 2
Oleg Nikolaevich Chupakhin
, 
Valery Nikolaevich Charushin 1, 2
Valery Nikolaevich Charushin
10.1016/j.mencom.2018.07.017
Published 2018-06-29
Communication , Volume 28, Issue 4, 393-395
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Verbitskiy E. V. et al. New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 393-395.
GOST all authors (up to 50) Copy
Verbitskiy E. V., Baskakova S. A., Gerasimova N. A., Evstigneeva N. P., Zil'berberg N. V., Kungurov N. V., Kravchenko M. A., Rusinov G. L., Chupakhin O. N., Charushin V. N. New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 393-395.
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TY - JOUR
DO - 10.1016/j.mencom.2018.07.017
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.017
TI - New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents
T2 - Mendeleev Communications
AU - Verbitskiy, Egor Vladimirovich
AU - Baskakova, Svetlana Anatol'evna
AU - Gerasimova, Natal’ya Avenirovna
AU - Evstigneeva, Natal’ya Petrovna
AU - Zil'berberg, Natal’ya Vladimirovna
AU - Kungurov, Nikolay Vasil'evich
AU - Kravchenko, Marionella Anatol'evna
AU - Rusinov, Gennady Leonidovich
AU - Chupakhin, Oleg Nikolaevich
AU - Charushin, Valery Nikolaevich
PY - 2018
DA - 2018/06/29
PB - Mendeleev Communications
SP - 393-395
IS - 4
VL - 28
ER -
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@article{2018_Verbitskiy,
author = {Egor Vladimirovich Verbitskiy and Svetlana Anatol'evna Baskakova and Natal’ya Avenirovna Gerasimova and Natal’ya Petrovna Evstigneeva and Natal’ya Vladimirovna Zil'berberg and Nikolay Vasil'evich Kungurov and Marionella Anatol'evna Kravchenko and Gennady Leonidovich Rusinov and Oleg Nikolaevich Chupakhin and Valery Nikolaevich Charushin},
title = {New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.017},
number = {4},
pages = {393--395},
doi = {10.1016/j.mencom.2018.07.017}
}
MLA
Cite this
MLA Copy
Verbitskiy, Egor Vladimirovich, et al. “New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents.” Mendeleev Communications, vol. 28, no. 4, Jun. 2018, pp. 393-395. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.017.

Abstract

A facile synthetic approach to 5-arylamino-4-(5-nitrofuran- 2-yl)pyrimidines by the Buchwald–Hartwig cross-coupling with various anilines has been developed. All synthesized compounds demonstrated a significant level of in vitro antibacterial activity against Neisseria gonorrhoeae, Streptococcus pyogene and Staphylococcus aureus, including their drug-resistant strains, which is much higher than that of the commercial drug Spectinomycin.

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