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Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity

Evgeniya Vladimirovna Nurieva 1
Evgeniya Vladimirovna Nurieva
, 
Tatiana Petrovna Trofimova 1, 2
Tatiana Petrovna Trofimova
, 
Alexander Aleksandrovich Alexeev 1
Alexander Aleksandrovich Alexeev
, 
Alexey N Proshin 3
Alexey N Proshin
, 
Ekaterina Aleksandrovna Chesnakova 4
Ekaterina Aleksandrovna Chesnakova
,  , 
Konstantin Alexandrovich Lyssenko 5
Konstantin Alexandrovich Lyssenko
, 
Marina Vladimirovna Filimonova 4
Marina Vladimirovna Filimonova
, 
Sergei Olegovich Bachurin 3
Sergei Olegovich Bachurin
, 
Ol'ga Nikolaevna Zefirova 1, 3
Ol'ga Nikolaevna Zefirova
10.1016/j.mencom.2018.07.016
Published 2018-06-29
Communication , Volume 28, Issue 4, 390-392
11
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Nurieva E. V. et al. Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 390-392.
GOST all authors (up to 50) Copy
Nurieva E. V., Trofimova T. P., Alexeev A. A., Proshin A. N., Chesnakova E. A., Grishin Y. K., Lyssenko K. A., Filimonova M. V., Bachurin S. O., Zefirova O. N. Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 390-392.
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TY - JOUR
DO - 10.1016/j.mencom.2018.07.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.016
TI - Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity
T2 - Mendeleev Communications
AU - Nurieva, Evgeniya Vladimirovna
AU - Trofimova, Tatiana Petrovna
AU - Alexeev, Alexander Aleksandrovich
AU - Proshin, Alexey N
AU - Chesnakova, Ekaterina Aleksandrovna
AU - Grishin, Yuri Konstantinovich
AU - Lyssenko, Konstantin Alexandrovich
AU - Filimonova, Marina Vladimirovna
AU - Bachurin, Sergei Olegovich
AU - Zefirova, Ol'ga Nikolaevna
PY - 2018
DA - 2018/06/29
PB - Mendeleev Communications
SP - 390-392
IS - 4
VL - 28
ER -
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@article{2018_Nurieva,
author = {Evgeniya Vladimirovna Nurieva and Tatiana Petrovna Trofimova and Alexander Aleksandrovich Alexeev and Alexey N Proshin and Ekaterina Aleksandrovna Chesnakova and Yuri Konstantinovich Grishin and Konstantin Alexandrovich Lyssenko and Marina Vladimirovna Filimonova and Sergei Olegovich Bachurin and Ol'ga Nikolaevna Zefirova},
title = {Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.016},
number = {4},
pages = {390--392},
doi = {10.1016/j.mencom.2018.07.016}
}
MLA
Cite this
MLA Copy
Nurieva, Evgeniya Vladimirovna, et al. “Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity.” Mendeleev Communications, vol. 28, no. 4, Jun. 2018, pp. 390-392. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.016.

Abstract

In a search of nitric oxide synthase inhibitors with prolonged vasoconstrictive activity, a series of lipophilic cyclohexafused 2-amino-2-thiazolines was obtained via cyclization of tert-butyl- or benzoyl-substituted N-(cyclohex-2-en-1-yl)thioureas. The crystal structure of intermediate N-[(3aRS,7aSR)-3a,4,5,6,7,7a-hexahydro-1,3-benzothiazol-2-yl]benzamide hydrobromide was determined by X-ray analysis. One compound was found to cause pronounced and prolonged vasoconstrictive effect after single injection to the Wystar rats with lipopolysaccharide induced acute endotoxic (vasodilatation) shock.

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