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PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold

, 
Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
, 
Yuliya Evgenievna Anisina 1
Yuliya Evgenievna Anisina
, 
Alexander Sergeyevich Goloveshkin 2
Alexander Sergeyevich Goloveshkin
, 
Ivan Evgenievich Ushakov 2
Ivan Evgenievich Ushakov
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.1016/j.mencom.2018.07.010
Published 2018-06-29
Communication , Volume 28, Issue 4, 372-374
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Elinson M. N. et al. PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 372-374.
GOST all authors (up to 50) Copy
Elinson M. N., Vereshchagin A. N., Anisina Y. E., Goloveshkin A. S., Ushakov I. E., Egorov M. P. PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 372-374.
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TY - JOUR
DO - 10.1016/j.mencom.2018.07.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.010
TI - PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold
T2 - Mendeleev Communications
AU - Elinson, Michail Nikolaevich
AU - Vereshchagin, Anatoly Nikolaevich
AU - Anisina, Yuliya Evgenievna
AU - Goloveshkin, Alexander Sergeyevich
AU - Ushakov, Ivan Evgenievich
AU - Egorov, Mikhail Petrovich
PY - 2018
DA - 2018/06/29
PB - Mendeleev Communications
SP - 372-374
IS - 4
VL - 28
ER -
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@article{2018_Elinson,
author = {Michail Nikolaevich Elinson and Anatoly Nikolaevich Vereshchagin and Yuliya Evgenievna Anisina and Alexander Sergeyevich Goloveshkin and Ivan Evgenievich Ushakov and Mikhail Petrovich Egorov},
title = {PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.010},
number = {4},
pages = {372--374},
doi = {10.1016/j.mencom.2018.07.010}
}
MLA
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Elinson, Michail Nikolaevich, et al. “PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold.” Mendeleev Communications, vol. 28, no. 4, Jun. 2018, pp. 372-374. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.07.010.

Abstract

The new multicomponent reaction comprises the triethylamine catalyzed assembling of salicylaldehydes, 2-aminoprop- 1-ene-1,1,3-tricarbonitrile and 3-methyl-2-pyrazolin-5-one in small amount of propanol, which affords substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 63–98% yields. This process is in agreement with PASE principles and opens the way to new chromeno[2,3-b]pyridine scaffold containing 3-methyl-2-pyrazolin-5-one fragment, which is promising for various biomedical applications.

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