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An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors

, 
Alexey Vladimirovich Borodachev 1
Alexey Vladimirovich Borodachev
, 
Andrey Sergeyevich Starikov 1
Andrey Sergeyevich Starikov
, 
Alexey V Afanasyev 1
Alexey V Afanasyev
, 
Maxim E Dmitriev 1
Maxim E Dmitriev
, 
Boris Vladimirovich Lednev 1
Boris Vladimirovich Lednev
, 
Valery Vladimirovich Ragulin 1
Valery Vladimirovich Ragulin
10.1016/j.mencom.2018.05.022
Published 2018-04-27
Communication , Volume 28, Issue 3, 295-296
3
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Vinyukov A. V. et al. An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 295-296.
GOST all authors (up to 50) Copy
Vinyukov A. V., Borodachev A. V., Starikov A. S., Afanasyev A. V., Dmitriev M. E., Lednev B. V., Ragulin V. V. An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 295-296.
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TY - JOUR
DO - 10.1016/j.mencom.2018.05.022
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.05.022
TI - An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors
T2 - Mendeleev Communications
AU - Vinyukov, Alexey Vladimirovich
AU - Borodachev, Alexey Vladimirovich
AU - Starikov, Andrey Sergeyevich
AU - Afanasyev, Alexey V
AU - Dmitriev, Maxim E
AU - Lednev, Boris Vladimirovich
AU - Ragulin, Valery Vladimirovich
PY - 2018
DA - 2018/04/27
PB - Mendeleev Communications
SP - 295-296
IS - 3
VL - 28
ER -
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@article{2018_Vinyukov,
author = {Alexey Vladimirovich Vinyukov and Alexey Vladimirovich Borodachev and Andrey Sergeyevich Starikov and Alexey V Afanasyev and Maxim E Dmitriev and Boris Vladimirovich Lednev and Valery Vladimirovich Ragulin},
title = {An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.05.022},
number = {3},
pages = {295--296},
doi = {10.1016/j.mencom.2018.05.022}
}
MLA
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Vinyukov, Alexey Vladimirovich, et al. “An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors.” Mendeleev Communications, vol. 28, no. 3, Apr. 2018, pp. 295-296. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.05.022.

Abstract

An acid-catalyzed three-component reaction between hypophosphorous acid, aldehydes and alkyl carbamates under mild conditions afforded bis(α-aminoalkyl)phosphinic acids. The proposed facile single-stage protocol is prospective for expansion of a range of phosphinic analogues of HIV protease inhibitors.

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